Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 GeneticVariation disease BEFREE Quantitative PCR (qPCR) and enzyme-linked immunosorbent assay (ELISA) were performed to detect the expression of interleukin 27 (IL-27) and Th2 cytokines (IL-4, IL-5, IL-13) from 22 patients diagnosed with AR and 20 normal controls. 31155348 2020
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 Biomarker disease BEFREE PGD<sub>2</sub> -CRTH2 and cysLTs-CysLT1 axes may activate tissue-resident ILC2s to produce Th2 cytokines, IL-5 and IL-13, leading to the development of allergic inflammation in AR. 31267527 2019
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 Biomarker disease BEFREE We sought to obtain mechanistic insight into how IL-17A and IL-13 regulate the epithelial production of eotaxin-3 representing eosinophilic inflammation in AR. 31403761 2019
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 AlteredExpression disease BEFREE Compared with the GFP-DC/AR group, mice in the Der p1-DC/AR group showed an ameliorated allergic response, a significant decrease in the levels of serum IgE, IgG1, and histamine, and a decrease in the expression of IL-4 and IL-13 mRNA and protein in the nasal mucosa. 30851701 2019
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 Biomarker disease BEFREE These findings show that CD4<sup>+</sup> T cells induce productions of IL-5 and IL-13 through MHCII on ILC2s in AR mice models. 30554982 2019
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 Biomarker disease BEFREE In mice with AR, AST2017-01 and chrysophanol markedly decreased number of rubs, IgE, histamine, thymic stromal lymphopoietin, tumor necrosis factor-α, interleukin (IL)-1β, IL-4, IL-5, and IL-13 in serum or nasal mucosa tissues. 30874868 2019
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 AlteredExpression disease BEFREE In addition, the expression levels of inflammatory factors were higher in the blood of mice with AR compared with the control group, while miR-let-7e overexpression inhibited these levels in AR mice and IL-13-stimulated NECs. 29545878 2018
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 Biomarker disease BEFREE The frequencies of sneezing and scratching, as well as the levels of IgE, IL-4, and IL-13, in the serum were higher in the AR group than in the control group (p<0.01), whereas all these parameters were decreased significantly after HRS treatment (p<0.05). 28215576 2018
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 GeneticVariation disease BEFREE However, the accumulating evidence does not support an association of IL-13 SNP rs1800925 and CD14 SNP rs2569190 with AR risk. 29687183 2018
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 AlteredExpression disease BEFREE AR mice shown significantly increased Th2 and Th17 cell ratio in spleen, IL-17 level in serum, IL-5 and IL-13 levels in NALF but a lower number of IL-33-positive epithelial cells and Th1 response (Th1 and Tbet<sup>+</sup>Th1 cell ratio in the spleen and serum IFN-γ level) than the control mice.1,25-(OH)<sub>2</sub>D<sub>3</sub> treatment significantly decreased the number of sneezing, nasal rubbing, OVA-sIgE and IL-17 in serum, IL-5 and IL-13 levels in NALF, Th17 cell ratio in the spleen and the histological of nasal mucosal but increased the number of IL-33-positive epithelial cells in AR mice. 28412624 2017
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 GeneticVariation disease BEFREE After adjustments, the presence of the IL13 rs20541A- allele (OR 3.06, 95% CI 1.42-6.58, p = 0.004) or multisensitization (adjusted OR 4.59, 95% CI 1.48-14.26, p = 0.008) was associated with AR/AC asthma. 28273659 2017
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 Biomarker disease BEFREE As IL13, a pleiotropic cytokine, may be important in conferring susceptibility to AR, the aim of the present work was to assess the relationship between a CpG island methylation status at the upstream of IL13 gene and house dust mite (HDM)-sensitized AR in Han Chinese subjects. 26399722 2016
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 Biomarker disease BEFREE miR-143 inhibits interleukin-13-induced inflammatory cytokine and mucus production in nasal epithelial cells from allergic rhinitis patients by targeting IL13Rα1. 25529447 2015
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 GeneticVariation disease BEFREE Gene-environment interactions between IL-13 (rs20541) and antibiotics or mold may play a role in AR. 24973272 2014
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 GeneticVariation disease BEFREE This meta-analysis supported that IL-13 SNP rs20541 was associated with AR, particularly in Asians. 23545317 2013
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 GeneticVariation disease BEFREE Association of interleukin-13 SNP rs20541 (Arg>Gln) to allergic rhinitis in an Asian population of ethnic Chinese in Singapore. 23954258 2013
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 GeneticVariation disease BEFREE The risk of current AR also increased in subjects with GA or AA at nucleotide 2044 in IL13 who had been exposed to mold in the home during infancy (adjusted odds ratio, 3.27; 95% CI, 1.75-6.11) compared with subjects who had GG at this position and had not been exposed to mold (adjusted odds ratio, 3.27; 95% CI, 1.75-6.11). 22846750 2012
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 GeneticVariation disease BEFREE The aim of the present study was to conduct a meta-analysis assessing the possible association of IL-13 SNP rs1800925 with allergic rhinitis risk. 22750299 2012
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 GeneticVariation disease BEFREE The IL-13R A(1) +1398 A/G polymorphism does not contribute to asthma or allergic rhinitis susceptibility, yet serum IL-13 can be used as a marker in atopic diseases and to differentiate between atopic and non-atopic asthma. 21425907 2011
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 GeneticVariation disease BEFREE We conclude that there is evidence for an overall association between IL13 SNP rs20541 and increased risk of AR, especially in mixed-age populations. 21309855 2011
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 GeneticVariation disease BEFREE However, a recent meta-analysis using data from these 6 studies has shown that the A allele of IL13 SNP rs20541 was associated with an increased risk of allergic rhinitis, whereas no such relationship existed between IL13 SNP rs1800925 and allergic rhinitis. 22023794 2011
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 GeneticVariation disease BEFREE A model with rs1058240, rs379568, and rs4143094 (GATA3) and rs1800925 (IL13) and their interactions was selected to predict rhinitis and positive SPT responses. rs1058240 was associated with rhinitis and allergic rhinitis (P < .05), and the gene-gene interaction rs1058240:rs1800925 was associated with rhinitis (P = .043). 18037162 2008
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 GeneticVariation disease BEFREE Our results suggest that the IL-13 exon 4 G2044A polymorphism confers susceptibility to the development of allergic rhinitis in Koreans, whereas the IL-4Ralpha Gln551Arg polymorphism is not related to allergic rhinitis. 17091279 2007
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 GeneticVariation disease BEFREE A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis. 12928861 2003
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.400 Biomarker disease BEFREE Environmental antigen-induced IL-13 responses are elevated among subjects with allergic rhinitis, are independent of IL-4, and are inhibited by endogenous IFN-gamma synthesis. 9862737 1998