Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 AlteredExpression disease BEFREE Our results lead us to propose a new pathophysiological animal model for induction of viral-related steatosis whereby the core protein of HCV targets microsomal triglyceride transfer protein activity and modifies hepatic VLDL assembly and secretion. 11818366 2002
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 AlteredExpression disease BEFREE We conclude that 1) HFD leads to ApoB100/MTP suppression reducing export of lipids; 2) castration promotes progression to steatohepatitis through activation of the ER stress pathway and enhancement of macrovesicular droplet protein expression; and 3) testosterone suppresses ER stress, inhibits the formation of macrovesicular lipid droplets, promotes lipid export, and ameliorates steatohepatitis induced by HFD and castration. 28928235 2018
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 AlteredExpression disease BEFREE Reductions in microsomal triglyceride transfer protein mRNA and activity are related to steatosis in HCV-3 infected patients. 18460919 2008
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 AlteredExpression disease BEFREE These results suggest that reduced MTP activity is crucial to development of alcoholic fatty liver, while promotion of MTP activity by HGF might serve as a therapeutic measure against alcoholic liver steatosis. 11830326 2002
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 AlteredExpression disease BEFREE Collectively, these results imply that DDX3 regulates MTP gene expression and lipid homeostasis through interplay with HNF4 and SHP, which may also reveal a novel mechanism of HCV-induced steatosis. 28128295 2017
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 AlteredExpression disease BEFREE Impaired expression of microsomal triglyceride transfer protein (MTTP) contributed to steatosis, which was reversed by in vivo restoration of Mttp expression. 22820290 2012
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 AlteredExpression disease BEFREE MTP mRNA levels showed a statistically significant (P = .001) inverse correlation with the degree of steatosis, independently of the HCV genotype. 16697730 2006
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 Biomarker disease CTD_human This steatosis was associated with aberrant microsomal apolipoprotein (apo) B-100 and microsomal triglyceride transfer protein (MTP) content, hypotriglyceridemia, hypocholesterolemia and abnormalities in both circulating lipoprotein composition and size. 17303181 2007
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 Biomarker disease BEFREE Intestine-specific inhibitors of MTP decrease chylomicron biogenesis and improve insulin sensitivity in experimental animals and, while overcoming hepatic steatosis, may have significant gastrointestinal side effects that could limit their use in humans. 25552696 2015
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 Biomarker disease BEFREE Comprehensive knowledge about the structure-function of MTP might help design new molecules that avoid steatosis. 26224785 2015
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 Biomarker disease BEFREE Yet, the development of MTP inhibitors to lower plasma lipid concentrations has been hindered by adverse effects on hepatic steatosis. 24201112 2013
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 GeneticVariation disease BEFREE In addition, mutations in apolipoprotein B and microsomal triglyceride transfer protein cause hepatic steatosis, in concordance with drugs that inhibit these targets. 26859812 2016
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 GeneticVariation disease BEFREE Although no genetic associations with advanced NAFLD have been replicated in large studies, preliminary data suggest that polymorphisms in the genes encoding microsomal triglyceride transfer protein, superoxide dismutase 2, the CD14 endotoxin receptor, tumor necrosis factor-alpha, transforming growth factor-beta, and angiotensinogen may be associated with steatohepatitis and/or fibrosis. 18445359 2008
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 GeneticVariation disease BEFREE The TM6SF2 E167K substitution promotes steatosis and lipid abnormalities in part by altering TM6SF2 and microsomal triglyceride transfer protein expression and differentially impacts CHC and chronic hepatitis B viral load, while effects on fibrosis are marginal.(Hepatology 2016;64:34-46). 26822232 2016
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 GeneticVariation disease BEFREE Chronic hepatitis C patients with the MTP -493T allele reveal higher grades of steatosis, indicating a relevant contribution to liver fat accumulation, particularly in HCV non-3 patients. 19018985 2009
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 GeneticVariation disease BEFREE Carriage of a SNP in the microsomal triglyceride transfer protein (MTTP) increased the risk of steatosis, but only in patients with HCV genotype 3 (rs1800803, OR=3.4, 95% CI=2.4-4.9, p=0.001). 21236304 2011
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 GeneticVariation disease BEFREE I/I genotype of MTTP gene frequency in the drinkers with fatty livers was 85.4%, which was significantly higher than that in the drinkers without fatty liver, which was 68.4% (P=0.013). 19262398 2009
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 GeneticVariation disease BEFREE The functional G/T MTP polymorphism do not seem to play any role in the development of steatosis in chronic hepatitis C. 16458034 2006
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 GeneticVariation disease BEFREE Genetic variation in the microsomal triglyceride transfer protein (-493G/T) is associated with hepatic steatosis in patients infected with hepatitis C virus. 28356060 2017
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 GeneticVariation disease BEFREE Circulating concentrations of adipokines (ie, tumor necrosis factor-alpha, adiponectin, resistin, leptin, and interleukin-6), markers of nitrosative stress (nitrotyrosine), dietary habits, and MTP -493G/T polymorphism were cross-sectionally related to the presence and severity of insulin resistance (homeostasis model assessment index for insulin resistance: >or=2), the metabolic syndrome, and fatty liver in 64 nonobese nondiabetic patients with NAFLD (33 insulin-sensitive and 31 insulin-resistant subjects) and 74 control subjects without liver disease who were matched for sex, BMI, homeostasis model assessment index for insulin resistance status, and the various features of the metabolic syndrome. 17823431 2007
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 GeneticVariation disease BEFREE MTTP polymorphisms and hepatic steatosis in individuals chronically infected with hepatitis C virus. 31321587 2019
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 GeneticVariation disease BEFREE In conclusion the presence of T allele of MTP-493G/T gene polymorphism predisposes patients infested with HCV genotype 3 to develop higher degree of fatty liver accumulation. 18482281 2008
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 GeneticVariation disease BEFREE We therefore assessed the association between a functional polymorphism in the promoter region of MTP gene (-493 G/T) and the biological features of steatohepatitis in Type II diabetic patients. 10990076 2000
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 GeneticVariation disease BEFREE The presence of at least one T allele in the -129 C/T polymorphism of the GCLC gene was independently associated with NASH (odds ratio 12.14, 95% confidence interval 2.01-73.35; P = 0.007), whereas, the presence of at least one G allele in the -493 G/T polymorphism of the MTP gene differed slightly between biopsy-proven NASH and simple steatosis. 19817962 2010
Entrez Id: 4547
Gene Symbol: MTTP
MTTP
0.400 GeneticVariation disease BEFREE Several MTTP polymorphisms have been reported relating to metabolic syndrome, hyperlipidemia and steatohepatitis. 26458397 2015