Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 65985
Gene Symbol: AACS
AACS
0.010 Biomarker disease BEFREE Betaine (900 ppm in vivo; 2 mM in vitro) and DHA (1% in vivo; 100 μM in vitro) supplementation both resulted in lower steatosis accompanied by the reduced expression of selected biomarkers in vivo and in vitro (<i>P</i> < 0.05).<b>Conclusion:</b> This study used adult laying hens to identify biomarkers for NAFLD and indicated that AACS, DPP4, GLUL, and GST could be considered to be potential diagnostic indicators for NAFLD in the future. 28077733 2017
Entrez Id: 13
Gene Symbol: AADAC
AADAC
0.010 Biomarker disease BEFREE Local factors or dysfunction of local proteins such as mutations or polymorphisms in hepatic microsomal lipase and arylacetamide deacetylase may contribute the severity of liver involvement, and steatosis may progress to cirrhosis in the early infancy in Chanarin-Dorfman syndrome. 20528790 2010
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.070 GeneticVariation disease BEFREE Hepatic miR-33a/miR-144 and their target gene ABCA1 are associated with steatohepatitis in morbidly obese subjects. 26945479 2016
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.070 AlteredExpression disease BEFREE We investigated the effect of cilostazol on hepatic ABCA1 expression and hepatic steatosis in diet-induced obesity mice model. 26362727 2015
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.070 AlteredExpression disease BEFREE Overall, we demonstrated that Trx-1 promotes RCT by upregulating ABCA1 expression through induction of nuclear translocation of LXRα, and protects liver from steatosis. 31280865 2019
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.070 AlteredExpression disease BEFREE In addition, LRP1 controls cellular cholesterol efflux by modulating the expression of ABCA1 and ABCG1, and hepatic LRP1 protects against diet-induced hepatic insulin resistance and steatosis through the regulation of insulin receptor trafficking. 28301372 2017
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.070 AlteredExpression disease BEFREE These results suggest that BBR can reduce steatosis by increasing ABCA1 protein levels through PKCδ to reduce the phosphorylation of serine residues in ABCA1. 29505790 2018
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.070 AlteredExpression disease BEFREE In this study, we determined the effects of IGF1 on ABCA1 expression in GH-deficient mice to clarify its effects on FL. 30130150 2018
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.070 AlteredExpression disease BEFREE Expression of apoA-I or ABCA1 can reduce steatosis by decreasing lipid storage in hepatocytes through lipid transport and may also reduce endoplasmic reticulum stress, further lessening hepatic steatosis. 24219083 2014
Entrez Id: 8647
Gene Symbol: ABCB11
ABCB11
0.020 Biomarker disease BEFREE Hepatic nuclear receptors are known to modulate genes controlling BA metabolism; thus, in this work we aimed to compare the expression of liver nuclear receptors -farnesoid X (FXR), small heterodimer partner (SHP) and liver X alpha (LXRα) receptors- and BA transporters -sodium+/taurocholate cotransporting polypeptide (NTCP) and bile salt export pump (BSEP)- in liver biopsy samples of patients with simple steatosis (SS) and NASH. 26019035 2016
Entrez Id: 8647
Gene Symbol: ABCB11
ABCB11
0.020 Biomarker disease BEFREE However, PFIC1 patients may develop aggravated diarrhea and steatohepatitis after LT. PFIC2 and PFIC3 patients have good outcomes after LT. 30250015 2018
Entrez Id: 10058
Gene Symbol: ABCB6
ABCB6
0.010 AlteredExpression disease BEFREE Increased ABCB6 expression correlated with liver disease progression with the pattern of expression being HCC > cirrhosis > steatosis. 21849266 2011
Entrez Id: 215
Gene Symbol: ABCD1
ABCD1
0.010 Biomarker disease BEFREE In summary, DMY likely modulates p62 and autophagy crosstalk with the Keap-1/Nrf2 pathway to alleviate liver steatosis and the inflammatory response in the pathological progression of ALD. 28419832 2017
Entrez Id: 9619
Gene Symbol: ABCG1
ABCG1
0.010 AlteredExpression disease BEFREE In addition, LRP1 controls cellular cholesterol efflux by modulating the expression of ABCA1 and ABCG1, and hepatic LRP1 protects against diet-induced hepatic insulin resistance and steatosis through the regulation of insulin receptor trafficking. 28301372 2017
Entrez Id: 64240
Gene Symbol: ABCG5
ABCG5
0.100 Biomarker disease HPO
Entrez Id: 64241
Gene Symbol: ABCG8
ABCG8
0.100 Biomarker disease HPO
Entrez Id: 51099
Gene Symbol: ABHD5
ABHD5
0.150 GeneticVariation disease BEFREE Severe steatohepatitis in a patient with a rare neutral lipid storage disorder due to ABHD5 mutation. 18644654 2008
Entrez Id: 51099
Gene Symbol: ABHD5
ABHD5
0.150 Biomarker disease BEFREE CGI-58 knockdown in mice using antisense oligonucleotide (ASO) treatment also leads to severe hepatic steatosis as well as increased hepatocellular diacylglycerol (DAG) content, a well-documented trigger of insulin resistance. 23302688 2013
Entrez Id: 51099
Gene Symbol: ABHD5
ABHD5
0.150 GeneticVariation disease BEFREE We report here a new mutation in comparative gene identification-58 (CGI-58) gene causing syndactyly and steatohepatitis induced early cirrhosis. 22245374 2012
Entrez Id: 51099
Gene Symbol: ABHD5
ABHD5
0.150 GeneticVariation disease BEFREE Steatohepatitis and unsuspected micronodular cirrhosis in Dorfman-Chanarin syndrome with documented ABHD5 mutation. 15127008 2004
Entrez Id: 51099
Gene Symbol: ABHD5
ABHD5
0.150 Biomarker disease HPO
Entrez Id: 51099
Gene Symbol: ABHD5
ABHD5
0.150 GeneticVariation disease BEFREE Mutations in ABHD5 gene are associated with the onset of Chanarin-Dorfman syndrome (CDS), a rare autosomal recessive lipid storage disorder, characterized by non-bullous congenital ichthyosiform erythroderma (NCIE), hepatomegaly and liver steatosis. 24628803 2014
Entrez Id: 31
Gene Symbol: ACACA
ACACA
0.040 AlteredExpression disease BEFREE Interestingly, LXRα, ACC1 and FAS expression had an inverse relation with the grade of steatosis. 25474087 2014
Entrez Id: 31
Gene Symbol: ACACA
ACACA
0.040 AlteredExpression disease BEFREE PGPIPN alleviated alcohol-induced cell steatosis and injuries by regulating the gene expressions and/or activities of ACC, PPAR-γ, CHOP and Caspase-3. 29152143 2017
Entrez Id: 31
Gene Symbol: ACACA
ACACA
0.040 AlteredExpression disease BEFREE Furthermore, CBD improved alcohol-induced hepatic metabolic dysregulation and steatosis by restoring changes in hepatic mRNA or protein expression of ACC-1, FASN, PPARα, MCAD, ADIPOR-1, and mCPT-1. 28935932 2017