Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE We assessed the familial correlation of PRO-C3 concentration, the shared gene effects between PRO-C3 concentration and liver steatosis and fibrosis, and the association between PRO-C3 concentration and genetic variants in the patatin-like phospholipase domain-containing 3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2), membrane-bound O-acyltransferase domain-containing (MBOAT), and glucokinase regulator (CGKR) genes. 30859582 2019
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE NAFLD predisposition runs strongly in families and an allele in the PNPLA3 gene has shown a strong association with liver steatosis and hepatic inflammation. 21178608 2011
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE Compared to recipients with only the PNPLA3 GG allele or obesity (defined as body mass index > 25 kg/m(2)), steatosis was highly prevalent (71.4%) in PNPLA3 GG carriers with obesity. 26379412 2015
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE A nonsynonymous single nucleotide polymorphism rs738409 (rs738409" genes_norm="80339">I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) predisposes susceptibility to NAFLD; however, its association with steatosis grade is inconsistent in the literature. 23176674 2012
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE We conducted a meta-analysis to assess the association between patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 polymorphism and nonalcoholic fatty liver disease (NAFLD) and its subtypes simple steatosis(SS) and nonalcoholic steatohepatitis (NASH). 25791171 2015
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE 75 (42.4%) patients tested positive for a PNPLA3 minor/major risk allele (G/C:66; G/G:9) showed comparable fibrosis stages (median F2 vs. F2; p = 0.292) and similar amounts of hepatic steatosis (CAP: 203.5 ± 41.9 vs. 215.5 ± 59.7 dB/m; p = 0.563) as compared to patients without a PNPLA3 risk allele. 26599080 2015
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE A genetic variant in adiponutrin (PNPLA3) gene, rs738409 C/G, is associated with steatosis, severity, and progression of liver fibrosis in CHC patients, and predicts treatment outcome in difficult-to-cure HCV-infected patients with advanced fibrosis. 26389885 2015
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE Establishment and characterization of an iPSC line from a 58 years old high grade patient with nonalcoholic fatty liver disease (70% steatosis) with homozygous wildtype PNPLA3 genotype. 30081348 2018
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 AlteredExpression disease BEFREE We used real-time polymerase chain reaction (PCR) analysis to analyze the hepatic expression of PNPLA3 and lipid metabolism-related genes in 55 morbidly obese subjects with normal liver histology (NL, n = 18), simple steatosis (SS, n = 20), and non-alcoholic steatohepatitis (NASH, n = 17). 27128907 2016
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE In Italian and United Kingdom patients, adiponutrin genotype influenced alanine aminotransferase levels and the severity of steatosis. 20373368 2010
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE Frequencies of allele PNPLA3 rs738409(G) in individuals with steatosis and normal alanine aminotransferase (ALT) and AST levels were lower than in alcoholics without steatosis and normal ALT/AST (P(combined) = 0.03). 21254164 2011
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE In a case only analysis of G allele of rs738409 in PNPLA3 was associated with a decreased risk of zone 3 centered steatosis (OR = 0.46, 95% CI = 0.36-0.58; P = 5.15 x 10(-11)). 20648472 2010
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 Biomarker disease BEFREE PNPLA3 may be an important key to understand the mechanisms discriminating fatty liver with and without metabolic consequences. 19651814 2009
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 Biomarker disease BEFREE Recent studies have implicated PNPLA3 in the pathogenesis of hepatic steatosis. 20480550 2010
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE The rs738409 genetic variant in the patatin-like phospholipase domain-containing 3 (PNPLA3, adiponutrin) gene has been implicated as a genetic determinant of the entire spectrum of liver diseases, ranging from steatosis, chronic hepatitis, cirrhosis and ultimately to HCC. 23333103 2013
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE A common variant in PNPLA3 increases the risk of hepatic steatosis in humans. 19224197 2009
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 Biomarker disease BEFREE The PNPLA3 p.148 I/M or M/M variants and CD4(+) cell count were the only independent predictors of severe steatosis in patients with HCV non-3 genotypes. 26806136 2016
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE The genetic polymorphism I148M of the patatin-like phospholipase domain-containing 3 (PNPLA3) is associated with hepatic steatosis and its progression to steatohepatitis (NASH), fibrosis and cancer. 29116096 2017
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE PNPLA3 rs738409[G] allele was significantly correlated with severe steatosis (P = 0.04), severe fibrosis at the time of enrollment (P = 0.0005) and fibrosis progression with an OR of 10.31 (95% CI 1.06 - 99.59, P = 0.04), after a mean follow-up time of 62.85 (95%CI: 52.21 - 76.15) months. 31642820 2019
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE Regarding the latter, a sequence variation within the gene coding for patatin-like phospholipase encoding 3 (PNPLA3, rs738409) was found to modulate steatosis, necroinflammation and fibrosis in NAFLD. 22110053 2012
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE PNPLA3 p.148M/M genotype was negatively associated with SVR and early viral kinetics independently of steatosis, albeit only in difficult-to-cure G1/4 patients with advanced fibrosis, whereas stratification for the p.148M/M PNPLA3 genotype unmasked an association between IL28B CC genotype and more severe liver fibrosis. 22530607 2012
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE However, IL28B rs12979860 and PNPLA3 rs738409 modify steatosis. 26259026 2016
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE Moreover, we genotyped the same patients for the patatin-like phospholipase-containing domain 3 (PNPLA3) I148M polymorphism, which is implicated in the development of liver steatosis. 25250621 2014
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE Multivariate logistic regression identified PNPLA3 G allele (OR: 2.469, CI 95%: 1.203-5.068; p=0.014) and pediatric age (OR: 4.348; 1.577-11.905; p=0.004) as independent variables associated with moderate/severe steatosis. 25678388 2015
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE This meta-analysis pooled four studies with 1135 cases of chronic hepatitis B (CHB) to evaluate the impact of PNPLA3 SNP on liver steatosis and also pooled five studies with 3713 cases of CHB to evaluate the impact of PNPLA3 SNP on cirrhosis. 29218813 2018