Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE These studies indicate that SIRT1 serves as a negative regulator of UPR signaling in T2DM and that SIRT1 attenuates hepatic steatosis, ameliorates insulin resistance, and restores glucose homeostasis, largely through the inhibition of mTORC1 and ER stress. 21321189 2011
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 AlteredExpression disease BEFREE SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis. 20033348 2011
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKα/SREBP1 signaling pathway. 28449683 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE We are the first to demonstrate that the SIRT1/HMGB1 pathway is a key therapeutic target for controlling NAFLD inflammation and that SalB confers protection against HFD- and PA-induced hepatic steatosis and inflammation through SIRT1-mediated HMGB1 deacetylation. 26525891 2016
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. 21540183 2011
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 AlteredExpression disease BEFREE A novel finding of this study was the observation that expression of GLP-1R is proportional to exendin-4 concentration and exendin-4 could attenuate fatty liver through activation of Sirt1. 22363635 2012
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis. 24486702 2015
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Molecularly, prevention of steatosis in the absence of REGγ entails elevated SirT1, a deacetylase regulating autophagy and metabolism. 24011073 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 AlteredExpression disease BEFREE Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. 20071779 2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE The SIRT1/heat shock factor 1/HSP pathway is essential for exenatide-alleviated, lipid-induced ER stress and hepatic steatosis, which provides evidence for a molecular mechanism to support exenatide and incretin mimetics as promising therapeutics for obesity-induced hepatic steatosis.(Hepatology 2017;66:809-824). 28439947 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Emerging roles of SIRT1 in fatty liver diseases. 28808418 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 GeneticVariation disease BEFREE In mice, hepatic deletion of Sirt1 promotes steatosis, inflammation, and fibrosis in response to ethanol challenge. 24262277 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human These studies indicate that SIRT1 serves as a negative regulator of UPR signaling in T2DM and that SIRT1 attenuates hepatic steatosis, ameliorates insulin resistance, and restores glucose homeostasis, largely through the inhibition of mTORC1 and ER stress. 21321189 2011
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human The miR-34a/NAMPT axis presents a potential target for treating obesity- and aging-related diseases involving SIRT1 dysfunction like steatosis and type 2 diabetes. 23834033 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human These studies indicate that SIRT1 serves as a negative regulator of UPR signaling in T2DM and that SIRT1 attenuates hepatic steatosis, ameliorates insulin resistance, and restores glucose homeostasis, largely through the inhibition of mTORC1 and ER stress. 21321189 2011
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1. 24442997 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human Hepatic overexpression of SIRT1 reduces steatosis and glucose intolerance in obese mice. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human We investigated mechanisms by which SIRT1 controls hepatic steatosis in mice. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human We investigated mechanisms by which SIRT1 controls hepatic steatosis in mice. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. 24210820 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human SIRT1-mediated activation of FGF21 prevents liver steatosis caused by fasting. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. 24210820 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human Prolonged fasting induced lipid deposition in livers of control mice, but severe hepatic steatosis in SIRT1 LKO mice. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human The miR-34a/NAMPT axis presents a potential target for treating obesity- and aging-related diseases involving SIRT1 dysfunction like steatosis and type 2 diabetes. 23834033 2014