Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 AlteredExpression disease BEFREE SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis. 20033348 2011
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. 21540183 2011
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human SIRT1-mediated activation of FGF21 prevents liver steatosis caused by fasting. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human SIRT1-mediated activation of FGF21 prevents liver steatosis caused by fasting. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis. 24486702 2015
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 AlteredExpression disease BEFREE A novel finding of this study was the observation that expression of GLP-1R is proportional to exendin-4 concentration and exendin-4 could attenuate fatty liver through activation of Sirt1. 22363635 2012
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1. 24442997 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1. 24442997 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 AlteredExpression disease BEFREE Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. 20071779 2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Emerging roles of SIRT1 in fatty liver diseases. 28808418 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human Hepatic overexpression of SIRT1 reduces steatosis and glucose intolerance in obese mice. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human Hepatic overexpression of SIRT1 reduces steatosis and glucose intolerance in obese mice. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human Hepatic overexpression of FGF21 in SIRT1 LKO mice increased the expression of genes that regulate fatty acid oxidation, decreased fasting-induced steatosis, reduced obesity, increased energy expenditure, and promoted browning of white adipose tissue. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human Hepatic overexpression of FGF21 in SIRT1 LKO mice increased the expression of genes that regulate fatty acid oxidation, decreased fasting-induced steatosis, reduced obesity, increased energy expenditure, and promoted browning of white adipose tissue. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human Here, we demonstrate that adenovirus-mediated overexpression of SIRT1 in the liver of diet-induced insulin-resistant low-density lipoprotein receptor-deficient mice and of genetically obese ob/ob mice attenuates hepatic steatosis and ameliorates systemic insulin resistance. 21321189 2011
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human Here, we demonstrate that adenovirus-mediated overexpression of SIRT1 in the liver of diet-induced insulin-resistant low-density lipoprotein receptor-deficient mice and of genetically obese ob/ob mice attenuates hepatic steatosis and ameliorates systemic insulin resistance. 21321189 2011
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 GeneticVariation disease BEFREE In mice, hepatic deletion of Sirt1 promotes steatosis, inflammation, and fibrosis in response to ethanol challenge. 24262277 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKα/SREBP1 signaling pathway. 28449683 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease BEFREE Molecularly, prevention of steatosis in the absence of REGγ entails elevated SirT1, a deacetylase regulating autophagy and metabolism. 24011073 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human Prolonged fasting induced lipid deposition in livers of control mice, but severe hepatic steatosis in SIRT1 LKO mice. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human Prolonged fasting induced lipid deposition in livers of control mice, but severe hepatic steatosis in SIRT1 LKO mice. 24184811 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Biomarker disease CTD_human SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. 24210820 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.400 Therapeutic disease CTD_human SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. 24210820 2014