Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.380 AlteredExpression disease BEFREE In conclusion, OA activates GPR40-PLC-calcium pathway to increase the expression of PPARδ and PPARδ further decreased the expression of PTEN to regulate insulin sensitivity in hepatic steatosis. 22209682 2012
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.380 Biomarker disease BEFREE We examined macroH2A1.1 and macroH2A1.2 protein expression levels in the liver of two murine models of fat-associated HCC, the high fat diet/diethylnistrosamine (DEN) and the phosphatase and tensin homolog (PTEN) liver specific knock-out (KO) mouse, and in human liver samples of subjects with steatosis or HCC, using immunoblotting and immunohistochemistry. 23372727 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.380 Biomarker disease BEFREE Therefore, we studied the effect of regular exercise on the development of HCC in male hepatocyte-specific PTEN-deficient mice (AlbCrePten(flox/flox)), which develop steatohepatitis and HCC spontaneously. 25623824 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.380 AlteredExpression disease BEFREE PTEN expression and steatosis were assessed in HCV-3a core protein-expressing Huh-7 cells and in mouse primary hepatocytes having miR-21-5p inhibited or genetically deleted respectively. 30938910 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.380 Biomarker disease BEFREE Genetic and molecular studies, particularly in the context of non-alcoholic fatty liver disease (NAFLD), support a critical role for PTEN in hepatic insulin sensitivity and the development of steatosis, steatohepatitis and fibrosis. 20460918 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.380 AlteredExpression disease BEFREE In nonalcoholic fatty liver disease, the intrahepatic down-regulation of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a critical mechanism leading to steatosis and its progression toward fibrosis and hepatocellular carcinoma. 21465511 2011
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.380 Biomarker disease BEFREE PTEN negatively regulates the enzymes involved in hepatic gluconeogenesis and lipid synthesis, which suggests that PTEN may be a therapeutic target for ketosis and fatty liver in dairy cows. 30819264 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.380 Biomarker disease CTD_human Toll-like Receptor 4 on Macrophage Promotes the Development of Steatohepatitis-related Hepatocellular Carcinoma in Mice. 27022031 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.380 Biomarker disease BEFREE Results show that disruption of PTEN resulted in steatohepatitis, fibrosis and caused hepatic induction of the Nrf2-dependent antioxidant system at least in part due to elevation of p62. 29799837 2018