Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 26073
Gene Symbol: POLDIP2
POLDIP2
0.010 Biomarker disease BEFREE Macrophage p38α promotes the progression of steatohepatitis by inducing pro-inflammatory cytokine secretion and M1 polarization. p38 inhibition protects against steatohepatitis. 30914267 2019
Entrez Id: 84868
Gene Symbol: HAVCR2
HAVCR2
0.010 Biomarker disease BEFREE In conclusion, Tim-3 is a promising protector in MCD-induced steatohepatitis by controlling ROS and the associated pro-inflammatory cytokine production in macrophages. 29735977 2019
Entrez Id: 359948
Gene Symbol: IRF2BP2
IRF2BP2
0.010 Biomarker disease BEFREE Herein, using gain- and loss-of-function approaches in mice, we demonstrated that while hepatocyte-specific Irf2bp2 knockout exacerbated high-fat diet-induced hepatic steatosis, insulin resistance and inflammation, hepatic Irf2bp2 overexpression protected mice from these metabolic disorders. 31529495 2019
Entrez Id: 1896
Gene Symbol: EDA
EDA
0.010 AlteredExpression disease BEFREE Increased levels of hepatic and secreted EDA were detected in steatosis, in vivo and in vitro. 31526774 2019
Entrez Id: 407008
Gene Symbol: MIR223
MIR223
0.010 Biomarker disease BEFREE Conclusion: HFD-fed miR-223KO mice develop a full spectrum of NAFLD, representing a clinically relevant mouse NAFLD model; miR-223 plays a key role in controlling steatosis-to-NASH progression by inhibiting hepatic Cxcl10 and Taz expression and may be a therapeutic target for the treatment of NASH. 30964207 2019
Entrez Id: 81631
Gene Symbol: MAP1LC3B
MAP1LC3B
0.010 Biomarker disease BEFREE Further analysis revealed that steatosis increased LC3B-II, a marker of autophagy, but caused blockade of autophagic flux associated with a lack of lysosomes. 31520816 2019
Entrez Id: 4189
Gene Symbol: DNAJB9
DNAJB9
0.010 Biomarker disease BEFREE Results showed that MDG-1 markedly blocked weight gain, and ameliorated lipid accumulation, liver damage and macrovesicular steatosis. 31491513 2019
Entrez Id: 80119
Gene Symbol: PIF1
PIF1
0.010 Biomarker disease BEFREE WD-fed PIF1 KO females developed mild hepatic steatosis and associated changes in liver gene expression that were absent in weight-matched, WD-fed female controls, linking hepatic steatosis to Pif1 ablation rather than increased body weight. 31136580 2019
Entrez Id: 6777
Gene Symbol: STAT5B
STAT5B
0.010 AlteredExpression disease BEFREE <i>Stat5/3<sup>Δhep/Δhep</sup></i> mice exhibited a marked reduction of STAT3, STAT5A and STAT5B proteins in the liver and developed steatosis, a phenotype that resembles mice lacking <i>Stat5a/b</i> in hepatocytes. 31443474 2019
Entrez Id: 54535
Gene Symbol: CCHCR1
CCHCR1
0.010 Biomarker disease BEFREE However, few studies has yet systematically evaluated the association between AIP and Fatty Liver (FL) and its advantage in FL prediction compared with BMI, waist, SBP, DBP, BG, ALT and AST. 31511022 2019
Entrez Id: 566
Gene Symbol: AZU1
AZU1
0.010 Biomarker disease BEFREE In IHCA, tumor hyperintensity on precontrast images and the underlying steatosis likely explain such iso- or hyperintensity, which do show reduced HBP contrast-agent uptake. 30937584 2019
Entrez Id: 2859
Gene Symbol: GPR35
GPR35
0.010 Biomarker disease BEFREE In this study, the role of GPR35 in hepatic steatosis was investigated using an in vitro model of liver X receptor (LXR)-mediated hepatocellular steatosis and an in vivo model of high fat diet-induced liver steatosis. 30304698 2019
Entrez Id: 7965
Gene Symbol: AIMP2
AIMP2
0.010 Biomarker disease BEFREE Macrophage p38α promotes the progression of steatohepatitis by inducing pro-inflammatory cytokine secretion and M1 polarization. p38 inhibition protects against steatohepatitis. 30914267 2019
Entrez Id: 107986209
Gene Symbol: H3P14
H3P14
0.010 AlteredExpression disease BEFREE Exogenous administration of N-Acetyl-L-cysteine (NAC), a small molecular inhibitor of ROS, remarkably suppressed caspase-1 p20 expression and IL-1β and IL-18 production in livers of Tim-3 KO mice, thus significantly reducing the severity of steatohepatitis induced by MCD. 29735977 2019
Entrez Id: 55226
Gene Symbol: NAT10
NAT10
0.010 AlteredExpression disease BEFREE <b>Results:</b> Analysis of data is accompanied with the significant histopathological changes (steatosis, ballooning and inflammation), increased lipid profile and hepatic enzyme activities (AST, ALT, ALP) plus TBARS as well as decreased antioxidants levels in NASH model. 31010354 2019
Entrez Id: 4170
Gene Symbol: MCL1
MCL1
0.010 AlteredExpression disease BEFREE In diet-induced obese mice, expression of EAT gene induces weight loss, improves glucose homeostasis, and attenuates hepatic steatosis. 31530849 2019
Entrez Id: 10254
Gene Symbol: STAM2
STAM2
0.010 Biomarker disease BEFREE In IHCA, tumor hyperintensity on precontrast images and the underlying steatosis likely explain such iso- or hyperintensity, which do show reduced HBP contrast-agent uptake. 30937584 2019
Entrez Id: 50616
Gene Symbol: IL22
IL22
0.010 AlteredExpression disease BEFREE Supplementation to restore intestinal levels of IAA protected mice from ethanol-induced steatohepatitis by inducing intestinal expression of IL-22 and REG3G, which prevented translocation of bacteria to liver. 30448775 2019
Entrez Id: 150094
Gene Symbol: SIK1
SIK1
0.010 AlteredExpression disease BEFREE Overexpression of SIK1 improved hyperglycaemia, hyperlipidaemia and fatty liver, reduced the expression of cAMP-response element binding protein (CREB)-regulated transcription co-activator 2 (CRTC2), phosphoenolpyruvate carboxykinase (PEPCK), glucose-6-phosphatase (G6Pase), pS577 SIK1, sterol regulatory element binding-protein-1c (SREBP-1c) and its target genes, including acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), and increased the expression of SIK1, pT182 SIK1 and pS171 CRTC2 in diabetic rat livers with the suppression of gluconeogenesis and lipid deposition. 31233505 2019
Entrez Id: 239
Gene Symbol: ALOX12
ALOX12
0.010 Biomarker disease BEFREE Ischemia reperfusion injury promotes recurrence of hepatocellular carcinoma in fatty liver via ALOX12-12HETE-GPR31 signaling axis. 31831037 2019
Entrez Id: 11266
Gene Symbol: DUSP12
DUSP12
0.010 AlteredExpression disease BEFREE At the molecular level, steatosis in the absence of DUSP12 was characterized by elevated apoptosis signal-regulating kinase 1 (ASK1), which mediates the mitogen-activated protein kinase (MAPK) pathway and hepatic metabolism. 30820969 2019
Entrez Id: 6717
Gene Symbol: SRI
SRI
0.010 AlteredExpression disease BEFREE Adenovirus-mediated overexpression of sorcin in Pb<sup>2+</sup> exposed hepatocytes and an in vivo mouse model ameliorates liver steatosis and hepatotoxicity. 31309533 2019
Entrez Id: 10451
Gene Symbol: VAV3
VAV3
0.010 Biomarker disease BEFREE Using Vav3-deficient mice as a model for chronic sympathoexcitation-associated disorders, we report here that afferent fibers of the hepatic branch of the vagus nerve are needed for the development of the peripheral sympathoexcitation, tachycardia, tachypnea, insulin resistance, liver steatosis and adipose tissue thermogenesis present in those mice. 30703063 2019
Entrez Id: 2730
Gene Symbol: GCLM
GCLM
0.010 GeneticVariation disease BEFREE We recently show that systemic GSH deficiency in mice harboring a global disruption of the glutamate-cysteine ligase modifier subunit (Gclm) gene confers protection against alcohol-induced steatosis. 31351176 2019
Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
0.010 Biomarker disease BEFREE Macrophage p38α promotes the progression of steatohepatitis by inducing pro-inflammatory cytokine secretion and M1 polarization. p38 inhibition protects against steatohepatitis. 30914267 2019