| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.170 | Biomarker | disease | BEFREE | This study aimed to evaluate the correlation between liver steatosis and iron overload in Polish patients with CHC compared to non-alcoholic fatty liver disease (NAFLD) and HFE-hereditary hemochromatosis (HH) patients. | 23924495 | 2013 | ||||
|
0.170 | GeneticVariation | disease | BEFREE | Serum ferritin concentrations were measured in 86 patients with histopathologically verified NAFLD (24 with steatosis and 62 with NASH) and 20 control subjects, they were tested for HFE gene mutations and their insulin resistance was measured. | 19267193 | 2010 | ||||
|
0.170 | GeneticVariation | disease | BEFREE | C282Y/H63D compound heterozygotes and patients with HFE genotypes other than C282Y/C282Y were more likely to have stainable Kupffer cell iron (31.1% vs. 9.5%; P=0.02), portal or lobular inflammation (28.9% vs. 15.6%; P=0.03), and steatosis (33.3% vs. 10.2%; P<0.01) on liver biopsy than C282Y homozygotes. | 19359997 | 2009 | ||||
|
0.170 | GeneticVariation | disease | BEFREE | All other common HFE genotypes--including C282Y-H63D compound heterozygosity--are not associated with significant biochemical and clinical expression in the absence of comorbid factors (e.g., alcohol, diabetes or steatohepatitis). | 19072401 | 2008 | ||||
|
0.170 | GeneticVariation | disease | BEFREE | The HFE gene heterozygosis H63D: a cofactor for liver damage in patients with steatohepatitis? Epidemiological and clinical considerations. | 17916170 | 2008 | ||||
|
0.170 | GeneticVariation | disease | BEFREE | Conversely, the prevalence of HFE mutations and serum ferritin values increased with the severity of steatosis. | 17640859 | 2007 | ||||
|
0.170 | GeneticVariation | disease | BEFREE | GBV-C infection, SENV infection, and HFE gene mutation were not considered to influence the development of NASH from simple fatty liver. | 15293136 | 2004 | ||||
|
0.170 | Biomarker | disease | HPO |