Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 AlteredExpression disease BEFREE Exogenous administration of N-Acetyl-L-cysteine (NAC), a small molecular inhibitor of ROS, remarkably suppressed caspase-1 p20 expression and IL-1β and IL-18 production in livers of Tim-3 KO mice, thus significantly reducing the severity of steatohepatitis induced by MCD. 29735977 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker disease BEFREE Importantly, animals exposed to adverse rearing were more vulnerable to metabolic dysregulation associated with the cafeteria diet, given that they consumed more energy, showed more severe hepatic steatosis and increased concentrations of the pro-inflammatory cytokine interleukin-1β than normally reared animals fed the cafeteria diet. 30211444 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 AlteredExpression disease BEFREE IL-1β expression coincided within the same areas of steatosis, inflammatory cell infiltration, collagen deposition and α-SMA expression in WT-HFD mice, that was significantly reduced in TKO-HFD mice. 29482933 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 AlteredExpression disease BEFREE IL-1 beta serum levels associate better with steatosis degree than liver function tests in morbidly obese population. 30505331 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker disease BEFREE Serum IL-1β and IL-18 concentrations correlated significantly with steatosis, NAFLD activity score, and transaminase levels. 28245087 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker disease BEFREE MCD diet-fed mice developed fibrotic steatohepatitis; MCC950 suppressed the increase in hepatic caspase 1 and IL-1β, lowered numbers of macrophages and neutrophils in the liver, and improved liver fibrosis. 28167322 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 GeneticVariation disease BEFREE Increased parenchymal damage and steatohepatitis in Caucasian non-alcoholic fatty liver disease patients with common IL1B and IL6 polymorphisms. 27730688 2016
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 AlteredExpression disease BEFREE Again, B6 C5(+) HFDG-fed mice developed more steatosis, liver centro-lobular inflammation and presented higher levels of liver IL-1β, IL-12p70, IL-17 and TFG-β than B6 C5(-) mice under the same conditions. 27477770 2016
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker disease BEFREE Age-related sensitivity to endotoxin-induced liver inflammation: Implication of inflammasome/IL-1β for steatohepatitis. 25847140 2015
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 AlteredExpression disease BEFREE Furthermore, the administration of IL-1 receptor antagonist to obese mice markedly reduced obesity-induced steatosis and hepatic lipogenic gene expression. 25216251 2014
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker disease BEFREE In this study Fifty HCV patients who underwent living donor liver transplantation were enrolled and factors that may accelerate HCV reinfection of the allograft such as donor's age and degree of liver steatosis, recipient's age, gender, BMI, MELD score, liver functions, HCV viral load, type of immunosuppressive drug, and genetic polymorphisms of IL28B, OAS, and IL1B were studied. 24695489 2014