Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 AlteredExpression disease BEFREE Laboratory examinations and abdominal ultrasonography revealed diabetes mellitus, insulin-resistance, dyslipidemia, decreased serum leptin levels (2.2 ng/mL), elevated serum hepatobiliary enzyme levels and fatty liver. 31708526 2020
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 Biomarker disease BEFREE We demonstrate that brain leptin protects from steatosis by promoting hepatic triglyceride export and decreasing de novo lipogenesis independently of caloric intake. 31222048 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 GeneticVariation disease BEFREE Fatty liver in lipodystrophy: A review with a focus on therapeutic perspectives of adiponectin and/or leptin replacement. 31071311 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 PosttranslationalModification disease BEFREE Liver-specific AlbCre+Cc1<sup>fl/fl</sup> mutants exhibited impaired insulin clearance and hyperinsulinemia at 2 months, followed by hepatic insulin resistance (assessed by hyperinsulinemic-euglycemic clamp analysis) and steatohepatitis at ~ 7 months of age, at which point visceral obesity and hyperphagia developed, in parallel to hyperleptinemia and blunted hypothalamic STAT3 phosphorylation in response to an intraperitoneal injection of leptin. 30664851 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 Biomarker disease BEFREE These results demonstrate that RSV restored leptin sensitivity in a cellular model of hepatic steatosis in a SIRT1-independent manner. 31842467 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 Biomarker disease BEFREE We found significant associations between increasing maternal prepregnancy BMI, being born large for gestational age, offspring level of sCD163, as well as offspring metabolic risk factors (decreasing adiponectin and HDL cholesterol and increasing leptin, HOMA of insulin resistance, and HOMA of insulin secretion) and degree of fatty liver. 31167890 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 Biomarker disease BEFREE MF treatment led to a decrease in food intake, the body and fat weights, the plasma levels of glucose, insulin and leptin, all increased in agouti-mice, to an improvement of the lipid profile and glucose sensitivity, and to a reduced fatty liver degeneration. 30870482 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 Biomarker disease BEFREE In the multiple regression analysis leptin, sObR, FLpI, waist-to-hip ratio, HbA1c, lipids, and HOMA-IR correlated independently with HS (P < 0.0001 for all). 30052309 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 PosttranslationalModification disease BEFREE Melatonin reverses leptin methylation and expression and decreases inflammation and chronic liver steatosis not via apoptosis or histone deacetylation (HDAC). 30424542 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 AlteredExpression disease BEFREE Circulating WISP-1/CCN4 positively correlated with body mass index, body fat percentage, leptin and triglyceride levels, hip circumference and fatty liver index. 29129025 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 Biomarker disease BEFREE Here we show that high intake of salt activates the aldose reductase-fructokinase pathway in the liver and hypothalamus, leading to endogenous fructose production with the development of leptin resistance and hyperphagia that cause obesity, insulin resistance, and fatty liver. 29507217 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 Biomarker disease BEFREE Both liver tissue and blood samples were processed to evaluate steatosis and NASH changes in histology (Oil Red, Sirius Red and H&E); presence of endothelial damage (CD31, Moesin/p-Moesin, Akt/p-Akt, eNOS/p-eNOS), oxidative stress (iNOS) and fibrosis (αSMA, Col1, PDGF, VEGF) proteins in liver tissue; and inflammatory (IL6, IL10, MCP-1, IL17α, TNFα), liver biochemical function, and hormonal (leptin, ghrelin, visfatin and insulin) alterations in plasma. 28710554 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 Biomarker disease BEFREE Aging is a significant risk factor for the development of obesity and hepatic steatosis associated with insulin and leptin resistance. 29575696 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 Biomarker disease BEFREE Alcohol exposure around conception increases obesity risk, alters plasma lipid and leptin profiles, and induces liver steatosis in a sex-specific manner. 29089335 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 Biomarker disease BEFREE High-fat diet (60% kcal) was used to induce fatty liver phenotype with parallel insulin and leptin resistance. 29660503 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 AlteredExpression disease BEFREE Our results suggest that mSJH exerts an anti-hepatic steatosis effect via activation of leptin and associated signaling cascades related to lipid metabolism. 28358008 2017
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 AlteredExpression disease BEFREE LEP levels showed an inverse relationship with the degree of steatosis, and RETN levels showed an inverse relationship with fibrosis stages. 28281237 2017
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 Biomarker disease BEFREE The probiotic mixture showed promise as a treatment for NAFLD pathogenesis, and may improve HFSD-induced steatosis through its effects on leptin, resistin, inflammatory biomarkers, and hepatic function markers. 28086768 2017
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 Biomarker disease CTD_human In vivo cytochrome P450 activity alterations in diabetic nonalcoholic steatohepatitis mice. 27712037 2017
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 Biomarker disease BEFREE We investigated the liver effect of leptin independently of insulin sensitization and appetite suppression using hepatocyte-specific Pten-deficient (AlbCrePtenff) mouse, a model of severe fatty liver with insulin hypersensitivity. 25415231 2015
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 Biomarker disease CTD_human Stevia-derived compounds attenuate the toxic effects of ectopic lipid accumulation in the liver of obese mice: a transcriptomic and metabolomic study. 25554529 2015
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 Biomarker disease CTD_human Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21. 23839791 2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 Biomarker disease CTD_human Chronic exposure to low doses of pharmaceuticals disturbs the hepatic expression of circadian genes in lean and obese mice. 24525044 2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 Biomarker disease BEFREE Rapid improvement of hepatic steatosis after initiation of leptin substitution in a leptin-deficient girl. 23651953 2013
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.400 AlteredExpression disease BEFREE Elevated leptin level seems to be a feature of steatosis, and it appears to increase as hepatocyte steatosis develops. 22215535 2012