Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 729838
Gene Symbol: GGTLC4P
GGTLC4P
0.100 GeneticVariation disease BEFREE The fatty liver index (FLI), which is calculated by the equation comprising waist circumference, body mass index (BMI), triglyceride, and gamma glutamyl transpeptidase (GGT), is frequently used for hepatic steatosis evaluation. 30981560 2020
Entrez Id: 729838
Gene Symbol: GGTLC4P
GGTLC4P
0.100 AlteredExpression disease BEFREE On univariate analysis, female donors (p = 0.051), RH graft (p = 0.001), no steatosis on ultrasonography (p = 0.042), lower TLV (p = 0.029), RLV (p = < 0.001), RLV-to-body weight ratio (RLVBWR) (p = < 0.001), preoperative alanine aminotransferase (ALT) level (p = 0.017), aspartate aminotransferase (AST) (p = 0.035) and higher POD 7 alkaline phosphatase (ALP) (p = 0.033), and POD 7 gamma-glutamyl transferase GGT (p = 0.006) were found to be predictors of greater liver regeneration. 31388890 2019
Entrez Id: 729838
Gene Symbol: GGTLC4P
GGTLC4P
0.100 GeneticVariation disease BEFREE In one liver biopsy specimen we found normal liver architecture without inflammation or steatosis in a patient with elevated ALT and GGT, negative for viral antibodies and autoantibodies. 31749874 2019
Entrez Id: 729838
Gene Symbol: GGTLC4P
GGTLC4P
0.100 Biomarker disease BEFREE The Hepatic Steatosis Index (HSI) and the Fatty Liver Index (FLI) were estimated using Body Mass Index (BMI), waist circumference, and fasting concentrations of glucose, triglycerides, and hepatic enzymes (ALT, AST, GGT). 30823422 2019
Entrez Id: 729838
Gene Symbol: GGTLC4P
GGTLC4P
0.100 Biomarker disease BEFREE Moreover, children with NAFLD had significantly higher activity of ALT (p < 0.001) and GGT (p < 0.001), HOMA-IR (p = 0.04), BMI (p = 0.046), waist circumference (p = 0.01) steatosis grade in ultrasound (p < 0.001) and TILC in <sup>1</sup>HMRS (p < 0.001) compared to children without NAFLD. 30208901 2018
Entrez Id: 729838
Gene Symbol: GGTLC4P
GGTLC4P
0.100 AlteredExpression disease BEFREE Our results suggest that the incidence of T2DM in the group with fatty liver is significantly higher than that in the normal population, and the rise of serum AST, GGT and ALT levels are risk factors independent of fatty liver for the development of T2DM after adjusting for confounding factors. 29936075 2018
Entrez Id: 729838
Gene Symbol: GGTLC4P
GGTLC4P
0.100 Biomarker disease BEFREE Significant correlations between IL-18 and ALT, GGT, triglycerides, hsCRP, and the degree of liver steatosis were demonstrated. 29854715 2018
Entrez Id: 729838
Gene Symbol: GGTLC4P
GGTLC4P
0.100 Biomarker disease BEFREE In ROC analysis only GGT, waist circumference and left IMT allowed to differentiate children with NAFLD from those without steatosis with GGT having the highest result (AUC=0.94). 30380561 2018
Entrez Id: 729838
Gene Symbol: GGTLC4P
GGTLC4P
0.100 Biomarker disease BEFREE CML was not correlated with liver steatosis (r=0.07, P=0.683), but was positively correlated with AST (r=0.34, P=0.04), GGT (r=0.38, P=0.023) and HbA1C (r=0.37, P=0.027). sRAGE tended to be higher in subjects with NFS<-1.455 compared with NFS>-1.455 (1287±450 n=36 vs. 1051±364 n=13, P=0.08). 28179090 2017
Entrez Id: 729838
Gene Symbol: GGTLC4P
GGTLC4P
0.100 GeneticVariation disease BEFREE Carriers of the rare CPT1b 66V (rs3213445) allele had significantly higher γ-glutamyl transpeptidase (GGT), glutamic oxaloacetic transaminase (GOT) and glutamic pyruvate transaminase (GPT) activities (P< 0·0001, P= 0·03 and P= 0·048, respectively) and a higher fatty liver index (FLI, P= 0·026). 22809552 2013
Entrez Id: 729838
Gene Symbol: GGTLC4P
GGTLC4P
0.100 Biomarker disease BEFREE The grade of steatosis correlates with GGT, platelet count, and BMI, while the NAS score of steatosis correlates with response to antiviral therapy. 20931285 2011
Entrez Id: 729838
Gene Symbol: GGTLC4P
GGTLC4P
0.100 Biomarker disease BEFREE Univariate analysis identified five parameters that significantly influenced steatosis: age >45 years, sex - female, IR (HOMA>2.5), BMI, central adiposity (as reflected by waist circumferences and high GGT-values). 20495737 2010
Entrez Id: 729838
Gene Symbol: GGTLC4P
GGTLC4P
0.100 Biomarker disease BEFREE We demonstrated that a lower serum adiponectin level was associated with male gender, higher gamma-glutamyltransferase (gamma-GGT), higher albumin, higher TNF-alpha, and steatosis grade. 18773295 2009
Entrez Id: 729838
Gene Symbol: GGTLC4P
GGTLC4P
0.100 AlteredExpression disease BEFREE For the current standard treatment with pegylated interferon alfa and ribavirin in patients with chronic hepatitis C, infection with HCV genotypes 2 and 3, baseline viral load below 400,000-800,000 IU/ml, Asian and Caucasian ethnicity, younger age, low GGT levels, absence of advanced fibrosis/cirrhosis, and absence of steatosis in the liver have been identified as independent pretreatment predictors of a sustained virologic response. 18715665 2008