Gene: HTRA1 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5654
Gene Symbol: HTRA1
HTRA1 		0.500 GeneticVariation group BEFREE Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects. 30859180 2019
Entrez Id: 5654
Gene Symbol: HTRA1
HTRA1 		0.500 Biomarker group BEFREE Screening of HTRA1 should be considered in patients with familial CSVD. 29305662 2018
Entrez Id: 5654
Gene Symbol: HTRA1
HTRA1 		0.500 GeneticVariation group BEFREE Thus, the CADASIL-like family disease may be caused by heterozygous HTRA1 gene mutation, which leads to autosomal dominant hereditary cerebral small vessel disease. 29561953 2018
Entrez Id: 5654
Gene Symbol: HTRA1
HTRA1 		0.500 GeneticVariation group BEFREE Recently, clinical studies have indicated that some patients with heterozygous mutations in HTRA1 may also suffer CSVD. 29797751 2018
Entrez Id: 5654
Gene Symbol: HTRA1
HTRA1 		0.500 GeneticVariation group BEFREE Heterozygous mutations of HTRA1 gene in patients with familial cerebral small vessel disease. 28782182 2017
Entrez Id: 5654
Gene Symbol: HTRA1
HTRA1 		0.500 GeneticVariation group BEFREE To elucidate the molecular mechanism of mutant HTRA1-dependent cerebral small vessel disease in heterozygous individuals. 27164673 2016
Entrez Id: 5654
Gene Symbol: HTRA1
HTRA1 		0.500 GeneticVariation group BEFREE Heterozygous HTRA1 mutations are associated with autosomal dominant cerebral small vessel disease. 26063658 2015
Entrez Id: 5654
Gene Symbol: HTRA1
HTRA1 		0.500 Biomarker group GENOMICS_ENGLAND Heterozygous HTRA1 mutations are associated with autosomal dominant cerebral small vessel disease. 26063658 2015
Entrez Id: 5654
Gene Symbol: HTRA1
HTRA1 		0.500 Biomarker group BEFREE Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling. 25369932 2014
Entrez Id: 5654
Gene Symbol: HTRA1
HTRA1 		0.500 GeneticVariation group BEFREE We recently demonstrated that mutations in the high-temperature requirement A (HTRA) serine peptidase 1 (HTRA1) gene cause a hereditary cerebral small-vessel disease, cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL). 21320870 2011
Entrez Id: 5654
Gene Symbol: HTRA1
HTRA1 		0.500 Biomarker group BEFREE Therefore, HTRA1 represents another new gene to be considered in future studies of cerebral small-vessel diseases, as well as alopecia and degenerative vertebral/disk diseases. 21215656 2011
Entrez Id: 5654
Gene Symbol: HTRA1
HTRA1 		0.500 GeneticVariation group CLINVAR