| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | disease | BEFREE | Both the reduced baseline mobility of X-RAR alpha and the ligand-induced slowing of X-RAR alpha could be attributed to the protein interaction domain contained within X. RXR alpha aberrantly colocalized within each X-RAR alpha; colocalization of RXR alpha with promyelocytic leukemia (PML)-RAR alpha resulted in reduced mobility of RXR alpha. | 15121864 | 2004 | ||||
|
0.070 | Biomarker | disease | BEFREE | Targeting the PML/RAR alpha translocation product triggers apoptosis in promyelocytic leukemia cells. | 9778041 | 1998 | ||||
|
0.070 | Biomarker | disease | BEFREE | The bcr1- and bcr3- promyelocytic leukemia/retinoic acid receptor alpha (PML/RAR alpha) are the two major fusion proteins expressed in acute promyelocytic leukemia (APL) patients. | 9242550 | 1997 | ||||
|
0.070 | Biomarker | disease | BEFREE | To examine, in newly diagnosed patients with acute promyelocytic leukemia (APL), the prognostic significance of secondary cytogenetic changes and the relationship between such changes and the two major promyelocytic leukemia-retinoic acid receptor alpha (PML-RAR alpha) mRNA types. | 9164186 | 1997 | ||||
|
0.070 | Biomarker | disease | BEFREE | Molecular analysis for the promyelocytic leukemia-retinoic acid receptor alpha (PML-RAR alpha) hybrid gene at diagnosis was performed in 16 patients by means of reverse transcription-polymerase chain reaction (RT-PCR) analysis, and all were RT-PCR+ for the hybrid gene. | 8695858 | 1996 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | cAMP signalling is decisive for recovery of nuclear bodies (PODs) during maturation of RA-resistant t(15;17) promyelocytic leukemia NB4 cells expressing PML-RAR alpha. | 8649787 | 1996 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | These results provide evidence of biological activity of PML-RAR alpha and recapitulate critical features of the promyelocytic leukemia phenotype. | 8394219 | 1993 |