×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
Biomarker
disease
GENOMICS_ENGLAND
Inotersen, a 2'-O-methyoxyethyl-modified antisense oligonucleotide, which acts by reducing the production of transthyretin , was recently demonstrated to improve disease course and quality of life in early hereditary transthyretin amyloidosis polyneuropathy in a 15-month Phase III study.
31118583
2019
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
Biomarker
disease
GENOMICS_ENGLAND
Inotersen: First Global Approval.
30120737
2018
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
Delayed diagnosis of transthyretin amyloidosis with a novel mutation (c.210T>A) in the transthyretin gene.
23317988
2013
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms.
19167329
2009
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
Transthyretin amyloidosis , also known as familial amyloidotic polyneuropathy, is an autosomal dominant disorder that results from a mutation in the gene encoding plasma transthyretin (TTR ).
17635579
2007
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
Genetic microheterogeneity of human transthyretin detected by IEF.
17503405
2007
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
A novel type of familial transthyretin amyloidosis , ATTR Asn124Ser, with co-localization of kappa light chains.
17577687
2007
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
A new transthyretin variant (Glu61Gly) associated with cardiomyopathy.
17453626
2007
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
The binding of 2,4-dinitrophenol to wild-type and amyloidogenic transthyretin.
16627944
2006
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
Cys114-linked dimers of transthyretin are compatible with amyloid formation.
16185074
2005
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
X-ray crystallographic studies of two transthyretin variants: further insights into amyloidogenesis.
15735344
2005
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
An unusual transthyretin gene missense mutation (TTR Phe33Val) linked to familial amyloidotic polyneuropathy.
15478468
2004
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
Identification of transthyretin variants by sequential proteomic and genomic analysis.
15217993
2004
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
A severe form of amyloidotic polyneuropathy in a Costa Rican family with a rare transthyretin mutation (Glu54Lys).
15214015
2004
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
Oculoleptomeningeal amyloidosis in a large kindred with a new transthyretin variant Tyr69His.
12771253
2003
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
A new transthyretin variant Leu55Gln in a patient with systemic amyloidosis.
12557757
2002
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
A definitive diagnosis of ATTR depends on the detection and identification of TTR variants.
11866053
2002
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
Misdiagnosis of hereditary amyloidosis as AL (primary) amyloidosis.
12050338
2002
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
Disulfide-bond formation in the transthyretin mutant Y114C prevents amyloid fibril formation in vivo and in vitro.
12403615
2002
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
Transthyretin stability as a key factor in amyloidogenesis: X-ray analysis at atomic resolution.
11243784
2001
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
Recurrent subarachnoid hemorrhage associated with a new transthyretin variant (Gly53Glu).
11445644
2001
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
A novel variant of transthyretin (Glu89Lys) associated with familial amyloidotic polyneuropathy.
10842705
2000
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
Heart failure caused by a novel amyloidogenic mutation of the transthyretin gene: ATTR Ala45Ser.
10842718
2000
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
The SSCP pattern suggested the presence of a mutation in exon 2, but was different from the pattern observed for a control representing the most common TTR mutation associated with FAP , i.e., TTR V30M.
10882995
2000
×
Entrez Id:
7276
Gene Symbol:
TTR
TTR
1.000
GeneticVariation
disease
UNIPROT
Serum analysis using immunoprecipitation and MALDI/TOF MS system can provide useful information when investigating FAP patients with diverse types of variant TTR .
10611950
1999