×
Entrez Id:
4359
Gene Symbol:
MPZ
MPZ
0.200
Biomarker
disease
MGD
Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons.
1384988
1992
×
Entrez Id:
10397
Gene Symbol:
NDRG1
NDRG1
0.200
Biomarker
disease
MGD
Ndrg1 in development and maintenance of the myelin sheath.
21303696
2011
×
Entrez Id:
2617
Gene Symbol:
GARS1
GARS1
0.200
Biomarker
disease
MGD
An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model.
16982418
2006
×
Entrez Id:
23095
Gene Symbol:
KIF1B
KIF1B
0.200
Biomarker
disease
MGD
Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta.
11389829
2001
×
Entrez Id:
4747
Gene Symbol:
NEFL
NEFL
0.200
Biomarker
disease
MGD
Neurofilament light polypeptide gene N98S mutation in mice leads to neurofilament network abnormalities and a Charcot-Marie-Tooth Type 2E phenotype.
25552649
2015
×
Entrez Id:
2617
Gene Symbol:
GARS1
GARS1
0.200
Biomarker
disease
MGD
Charcot-Marie-Tooth-linked mutant GARS is toxic to peripheral neurons independent of wild-type GARS levels.
22144914
2011
×
Entrez Id:
5376
Gene Symbol:
PMP22
PMP22
0.200
Biomarker
disease
MGD
Altered ion channels in an animal model of Charcot-Marie-Tooth disease type IA.
15703401
2005
×
Entrez Id:
121512
Gene Symbol:
FGD4
FGD4
0.200
Biomarker
disease
MGD
Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells.
23171661
2012
×
Entrez Id:
55526
Gene Symbol:
DHTKD1
DHTKD1
0.200
Biomarker
disease
MGD
DHTKD1 Deficiency Causes Charcot-Marie-Tooth Disease in Mice.
29661920
2018
×
Entrez Id:
81846
Gene Symbol:
SBF2
SBF2
0.200
Biomarker
disease
MGD
Mtmr13/Sbf2-deficient mice: an animal model for CMT4B2.
17855448
2007
×
Entrez Id:
1959
Gene Symbol:
EGR2
EGR2
0.200
Biomarker
disease
MGD
Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination.
15695336
2005
×
Entrez Id:
8898
Gene Symbol:
MTMR2
MTMR2
0.200
Biomarker
disease
MGD
Disruption of Mtmr2 produces CMT4B1-like neuropathy with myelin outfolding and impaired spermatogenesis.
15557122
2004
×
Entrez Id:
4359
Gene Symbol:
MPZ
MPZ
0.200
Biomarker
disease
MGD
Protein zero (P0)-deficient mice show myelin degeneration in peripheral nerves characteristic of inherited human neuropathies.
7581451
1995
×
Entrez Id:
4359
Gene Symbol:
MPZ
MPZ
0.200
Biomarker
disease
MGD
MpzR98C arrests Schwann cell development in a mouse model of early-onset Charcot-Marie-Tooth disease type 1B.
22689911
2012
×
Entrez Id:
79628
Gene Symbol:
SH3TC2
SH3TC2
0.200
Biomarker
disease
MGD
SH3TC2/KIAA1985 protein is required for proper myelination and the integrity of the node of Ranvier in the peripheral nervous system.
19805030
2009
×
Entrez Id:
10397
Gene Symbol:
NDRG1
NDRG1
0.200
Biomarker
disease
MGD
Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves.
15082788
2004
×
Entrez Id:
2705
Gene Symbol:
GJB1
GJB1
0.200
Biomarker
disease
MGD
Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice.
8790370
1996
×
Entrez Id:
4359
Gene Symbol:
MPZ
MPZ
0.200
Biomarker
disease
MGD
A nonsense mutation in myelin protein zero causes congenital hypomyelination neuropathy through altered P0 membrane targeting and gain of abnormal function.
30239779
2019
×
Entrez Id:
4000
Gene Symbol:
LMNA
LMNA
0.200
Biomarker
disease
MGD
Homozygous defects in LMNA, encoding lamin A/C nuclear-envelope proteins, cause autosomal recessive axonal neuropathy in human (Charcot-Marie-Tooth disorder type 2) and mouse.
11799477
2002
×
Entrez Id:
5376
Gene Symbol:
PMP22
PMP22
0.200
Biomarker
disease
MGD
Abnormal Schwann cell/axon interactions in the Trembler-J mouse.
9147228
1997
×
Entrez Id:
9896
Gene Symbol:
FIG4
FIG4
0.200
Biomarker
disease
MGD
Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration.
22581779
2012
×
Entrez Id:
90678
Gene Symbol:
LRSAM1
LRSAM1
0.200
Biomarker
disease
MGD
Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease.
23519028
2013
×
Entrez Id:
5376
Gene Symbol:
PMP22
PMP22
0.200
Biomarker
disease
MGD
Oral curcumin mitigates the clinical and neuropathologic phenotype of the Trembler-J mouse: a potential therapy for inherited neuropathy.
17701891
2007
×
Entrez Id:
1337
Gene Symbol:
COX6A1
COX6A1
0.200
Biomarker
disease
MGD
A mutation of COX6A1 causes a recessive axonal or mixed form of Charcot-Marie-Tooth disease.
25152455
2014
×
Entrez Id:
9990
Gene Symbol:
SLC12A6
SLC12A6
0.200
Biomarker
disease
MGD
Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold.
14532115
2003