Background and Purpose- Previously, murine models Krit1 <sup>+/-</sup> Msh2 <sup>-/</sup><sup>-</sup> and Ccm2 <sup>+/</sup><sup>-</sup> Trp53 <sup>-/</sup><sup>-</sup> showed a reduction or no effect on cerebral cavernous malformation (CCM) burden and favorable effects on lesional hemorrhage by the robust Rock (Rho-associated protein kinase) inhibitor fasudil and by simvastatin (a weak pleiotropic inhibitor of Rock).