Gene: KLF4 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9314
Gene Symbol: KLF4
KLF4 		0.030 Biomarker disease BEFREE Mechanistically, CDC42 depletion in ECs elicited increased MEKK3 (mitogen-activated protein kinase kinase kinase 3)-MEK5 (mitogen-activated protein kinase kinase 5)-ERK5 (extracellular signal-regulated kinase 5) signaling and consequent detrimental overexpression of KLF (Kruppel-like factor) 2 and KLF4, recapitulating the hallmark mechanism for CCM pathogenesis. 30732528 2019
Entrez Id: 9314
Gene Symbol: KLF4
KLF4 		0.030 AlteredExpression disease BEFREE Consistent with these findings in mice, we show that endothelial expression of KLF2 and KLF4 is increased in human familial and sporadic CCM lesions, and that a disease-causing human CCM2 mutation abrogates the MEKK3 interaction without affecting CCM complex formation. 27027284 2016
Entrez Id: 9314
Gene Symbol: KLF4
KLF4 		0.030 Biomarker disease BEFREE Our data unveil KLF4 as a therapeutic target for CCM. 26612856 2016