Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.040 Biomarker group BEFREE The differentiation in and/or recruitment to gastrointestinal, lung, and lymphoid tissues of CD11b<sup>+</sup> DCs requires NLRP3, but not apoptosis-associated speck-like protein containing a carboxy-terminal CARD (ASC) or caspase-1, during steady-state and chronic infection. 29281833 2017
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.040 Biomarker group BEFREE Western blot was used to detect the expression of key proteins in inflammatory signaling cascades including toll-like receptor 4 (TLR4), myeloid differentiation protein 88 (MyD88), nuclear factor-kappa B (NF-κB), Nod-like receptor family pyrin domain containing 3 (NLRP3), apoptosis-associated speck-like protein containing CARD (ASC), cysteinyl aspartate specific proteinase-1 (Caspase-1) and IL-1β, as well as insulin signaling in liver and prefrontal cortex of rats. 29864926 2018
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.040 Biomarker group BEFREE Moreover, this decoction inhibited nuclear entry of nuclear factor-kappa B (NF-<i>κ</i>B) with the reduction of phosphorylated protein of NF-<i>κ</i>B (p-NF-<i>κ</i>B) and inhibitor of NF-<i>κ</i>B alpha (p-I<i>κ</i>B<i>α</i>) and downregulated protein of nod-like receptor family pyrin domain-containing 3 (NLRP3), apoptosis-associated speck-like protein containing CARD (ASC), cysteinyl aspartate-specific proteinase-1 (Caspase-1), and IL-1<i>β</i> in liver and brain regions of CUMS rats. 29853787 2018
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.040 AlteredExpression group BEFREE At the molecular level, Western blot assays indicated that the <i>D. dasycarpus</i> extract attenuated oxazolone-induced activation of apoptosis-associated speck-like protein containing CARD (ASC), procaspase-1, NF-#B and mitogen-activated protein kinase (MAPKs) such as c-Jun N-terminal protein kinase (JNK) and p38.This study demonstrates that <i>D. dasycarpus</i> extract could protect skin cells against oxidative and inflammatory insult by modulating the intracellular levels of ROS, TNF-#, interleukin-1, interleukin-6, NLR family pyrin domain containing 3 (NLRP3) inflammasome generation, antioxidant enzyme activity and cell signaling pathways.<i>D. dasycarpus</i> extract also attenuated the expression of NF-#B in HaCaT keratinocytes and thereby effectively downregulated inflammatory responses in the skin.Furthermore, <i>D. dasycarpus</i> extract alleviated oxazolone-induced damage in mice. 29914105 2018