Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.040 | Biomarker | group | BEFREE | The differentiation in and/or recruitment to gastrointestinal, lung, and lymphoid tissues of CD11b<sup>+</sup> DCs requires NLRP3, but not apoptosis-associated speck-like protein containing a carboxy-terminal CARD (ASC) or caspase-1, during steady-state and chronic infection. | 29281833 | 2017 | ||||
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0.040 | Biomarker | group | BEFREE | Western blot was used to detect the expression of key proteins in inflammatory signaling cascades including toll-like receptor 4 (TLR4), myeloid differentiation protein 88 (MyD88), nuclear factor-kappa B (NF-κB), Nod-like receptor family pyrin domain containing 3 (NLRP3), apoptosis-associated speck-like protein containing CARD (ASC), cysteinyl aspartate specific proteinase-1 (Caspase-1) and IL-1β, as well as insulin signaling in liver and prefrontal cortex of rats. | 29864926 | 2018 | ||||
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0.040 | Biomarker | group | BEFREE | Moreover, this decoction inhibited nuclear entry of nuclear factor-kappa B (NF-<i>κ</i>B) with the reduction of phosphorylated protein of NF-<i>κ</i>B (p-NF-<i>κ</i>B) and inhibitor of NF-<i>κ</i>B alpha (p-I<i>κ</i>B<i>α</i>) and downregulated protein of nod-like receptor family pyrin domain-containing 3 (NLRP3), apoptosis-associated speck-like protein containing CARD (ASC), cysteinyl aspartate-specific proteinase-1 (Caspase-1), and IL-1<i>β</i> in liver and brain regions of CUMS rats. | 29853787 | 2018 | ||||
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0.040 | AlteredExpression | group | BEFREE | At the molecular level, Western blot assays indicated that the <i>D. dasycarpus</i> extract attenuated oxazolone-induced activation of apoptosis-associated speck-like protein containing CARD (ASC), procaspase-1, NF-#B and mitogen-activated protein kinase (MAPKs) such as c-Jun N-terminal protein kinase (JNK) and p38.This study demonstrates that <i>D. dasycarpus</i> extract could protect skin cells against oxidative and inflammatory insult by modulating the intracellular levels of ROS, TNF-#, interleukin-1, interleukin-6, NLR family pyrin domain containing 3 (NLRP3) inflammasome generation, antioxidant enzyme activity and cell signaling pathways.<i>D. dasycarpus</i> extract also attenuated the expression of NF-#B in HaCaT keratinocytes and thereby effectively downregulated inflammatory responses in the skin.Furthermore, <i>D. dasycarpus</i> extract alleviated oxazolone-induced damage in mice. | 29914105 | 2018 |