|
COMMD3-BMI1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In our study, elevated expression of IMPDH2 was observed at both the protein and mRNA levels in NPC cell lines than in NPEC2 Bmi-1.
|
28389646 |
2017 |
|
COMMD3-BMI1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bmi-1 may be a potential new target for the treatment of nasopharyngeal carcinoma displaying chemotherapy resistance.
|
26294655 |
2016 |
|
COMMD3-BMI1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
BMI-1 expression was found to be up-regulated and inversely correlated with miR-320a expression in NPC.
|
25171860 |
2014 |
|
COMMD3-BMI1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that Bmi-1 downregulation increases the radiosensitivity to CD44+ NPC CSC-LCs.
|
24927072 |
2014 |
|
COMMD3-BMI1
|
0.100 |
Biomarker
|
disease |
BEFREE |
The expression levels of SPARC mRNA and protein were markedly higher in NPC cell lines than in NPEC2 Bmi-1.
|
22321704 |
2012 |
|
COMMD3-BMI1
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, BMI-1 autoantibody as a biomarker has seldom been studied with the exception of nasopharyngeal carcinoma.
|
22132147 |
2011 |
|
COMMD3-BMI1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taking together, the BMI1-p16/CDK4 axis was involved in the artemisinin-driven G1 arrest in nasopharyngeal carcinoma cells, and these results indicated that a potential treatment that the combination of artemisinin and BMI-1 downregulation could enhance the growth inhibitory affects on nasopharyngeal carcinoma cells.
|
21445878 |
2011 |
|
COMMD3-BMI1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Ectopic expression of Bmi-1 can induce epithelial-mesenchymal transition (EMT) and enhance the motility and invasiveness of human nasopharyngeal epithelial cells (NPECs), whereas silencing endogenous Bmi-1 expression can reverse EMT and reduce the metastatic potential of nasopharyngeal cancer cells (NPCs).
|
21276221 |
2011 |
|
COMMD3-BMI1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The polycomb group protein B lymphoma Mo-MLV insertion region 1 homolog (Bmi-1) is dysregulated in various cancers, and its upregulation strongly correlates with an invasive phenotype and poor prognosis in patients with nasopharyngeal carcinomas.
|
19884659 |
2009 |
|
COMMD3-BMI1
|
0.100 |
Biomarker
|
disease |
BEFREE |
The showed that BMI-1 antibody as a potential marker of NPC may be rational, and could have diagnostic and prognostic value.
|
18094618 |
2008 |
|
COMMD3-BMI1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, BMI-1 depletion enhanced the chemosensitivity of NPC cells by inducing apoptosis; which is associated with inhibition of the PI3K/AKT pathway.
|
18452707 |
2008 |
|
COMMD3-BMI1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, high Bmi-1 expression positively correlated with poor prognosis of nasopharyngeal carcinoma patients.
|
16778197 |
2006 |