Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation disease BEFREE We concluded that there were the correlations between NPSCC subtypes with EBV infection and frequent intaking of pickled food, while aging, clinical recurrence, and TP53 gene mutations were independent predictors for the poor prognosis of nasopharyngeal carcinoma. 30964122 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression disease BEFREE Our data indicated that blocking p53 expression and mediated signal pathways contribute to the positive effects of miR-151a-3p on NPC cell proliferation, migration and invasion. 31652456 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker disease BEFREE Here, we show that caspase-3-mediated p21 cleavage involves p53 independent of triptolide (TPL)-induced S phase arrest in human type 1 nasopharyngeal carcinoma (NPC) cells. 31059711 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker disease BEFREE MDM2 inhibitor RG7388 potently inhibits tumors by activating p53 pathway in nasopharyngeal carcinoma. 31311404 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression disease BEFREE In conclusion, p53 expression is related to the survival of nasopharyngeal carcinoma. 30063067 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression disease BEFREE Silencing UBE4B induces nasopharyngeal carcinoma apoptosis through the activation of caspase3 and p53. 31040698 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker disease BEFREE As a small subpopulation of nasopharyngeal carcinoma (NPC), cancer stem-like cells (CSCs) function critically in multi-malignant behaviors, including tumorigenesis and metastasis; however, the expression pattern and regulatory role of miR-125a, miR-125b and p53 in CSCs derived from NPC remain unclear. 30655742 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation disease BEFREE Unlike in most human solid tumors, TP53 mutations are rare in nasopharyngeal carcinoma and EBV-associated gastric carcinoma tissues, suggesting a possibility that some EBV-encoded products suppress the functions of p53. 30209170 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression disease BEFREE On the whole, these findings indicate that COX-2 may play a critical role in chemotherapeutic resistance in NPC via the inhibition of chemotherapy-induced senescence via the inactivation of p53. 29956730 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker disease BEFREE Thus, our results revealed for the first time that INHBB could suppress anoikis resistance and migration of NPC cells by the TGF-β signaling pathway, decrease p53 overexpression, and could serve as a potential biomarker for NPC metastasis and prognosis as well as a therapeutic application. 30151927 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation disease BEFREE Among the 15 SNPs detected in the meta-analysis, miR-146a (rs2910164, C>G), HCG9 (rs3869062, A>G), HCG9 (rs16896923, T>C), MMP2 (rs243865, C>T), GABBR1 (rs2076483, T>C), and TP53 (rs1042522, C>G) were associated with decreased susceptibility to NPC, while GSTM1 (+/DEL), IL-10 (rs1800896, A>G), MDM2 (rs2279744, T>G), MDS1-EVI1 (rs6774494, G>A), XPC (rs2228000, C>T), HLA-F (rs3129055, T>C), SPLUNC1 (rs2752903, T>C; and rs750064, A>G), and GABBR1 (rs29232, G>A) were associated with increased susceptibility to NPC. 28881764 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression disease BEFREE Here, we showed that TP53-regulated inhibitor of apoptosis (TRIAP1) was aberrantly overexpressed and associated with poor survival in NPC patients. 27428374 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker disease BEFREE These miRNAs, mRNAs, and lncRNAs may participate in p53 downstream signaling pathways and play important roles in the carcinogenesis of NPC. 26462838 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker disease BEFREE Data also suggested that cellular miR-34b, miR-34c, miR-18a, miR‑200a/b, miR-449a, miR-31 and let-7 may be dysregulated in NPCs, and that the aberrant activation of their target genes in the p53 pathway and cell cycle enhance NPC cell survival and proliferation. 26330189 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker disease BEFREE In the present study, the effects of Nutlin-3 alone or in combination with cisplatin, a standard chemotherapeutic agent, were tested on C666-1 cells, an Epstein-Barr virus (EBV)-positive NPC cell line bearing wt p53. 26252575 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression disease BEFREE The observed downregulation of the protein level of p53 in cisplatin‑treated patients with nasopharyngeal carcinoma (NPC) indicates the association between cisplatin resistance, miR‑125a and miR‑125b. 26017674 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation disease BEFREE The results suggested that the Arg399Gln polymorphism of XRCC1 gene, the 1G/2G polymorphism of MMP-1 gene, the RsaI polymorphism of CYP2E1 gene, the -1306C>T polymorphism of MMP-2 gene and the Arg72Pro polymorphism of p53 gene might be related to increased risks of nasopharyngeal carcinoma under different genetic comparison models, while the Arg194Trp and Arg280His polymorphisms of XRCC1 gene and the 309T>G polymorphism of MDM2 gene might not contribute to the risk of nasopharyngeal carcinoma. 25481674 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation disease BEFREE Multivariate analysis showed that the p53 codon 72 Pro/Pro genotype [hazard ratio (HR), 0.300; 95% confidence interval (CI), 0.092-0.983; P=0.047] and heavy smoking (≥30 pack-years) (HR, 2.899; 95% CI, 1.349-6.229; P=0.006) are independent significant prognostic factors for PFS in patients with locoregionally advanced NPC. 24173110 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation disease BEFREE We showed that variants in p53 codon 72 may be an independent predictor for PFS and OS of NPC patients. 25526208 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation disease BEFREE Increased risk of NPC was observed among individuals carrying the variant allele and genotypes of P53 codon 72 (OR Pro vs. Arg = 1.32, 95% CI 1.18-1.47, P OR < 0.001; OR ProPro vs. ArgArg = 1.90, 95% CI 1.51-2.39, P OR < 0.001; OR ProArg + ProPro vs. ArgArg = 1.33, 95% CI 1.13-1.57, P OR = 0.001; OR ProPro vs. ArgArg + ProArg = 1.65, 95% CI 1.35-2.01, P OR < 0.001). 24114013 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker disease BEFREE Collectively, these results suggest that LOC401317 is directly regulated by p53 and exerts antitumor effects in HNE2 nasopharyngeal carcinoma cells. 25422887 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker disease CTD_human The genomic landscape of nasopharyngeal carcinoma. 24952746 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker disease BEFREE Expression of Epstein-Barr virus-encoded latent membrane protein (LMP-1), p16 and p53 proteins in nonendemic nasopharyngeal carcinoma (NPC): a clinicopathological study. 24606815 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker disease BEFREE Our results suggest that genetic variants in the PTEN, AKT1, MDM2 and p53 tumor suppressor-oncoprotein network may play roles in mediating the susceptibility to NPC in Chinese populations. 24632578 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation disease BEFREE These findings suggest that miR-34b/c rs4938723 and TP-53 Arg72Pro polymorphisms may singly or collaboratively contribute to the risk of NPC. 23504554 2013