Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.360 | AlteredExpression | phenotype | BEFREE | Paclitaxel also upregulated the expression of glutamate receptor subunits GluR1 and NR2B, decreased the expression of K<sup>+</sup>-Cl<sup>-</sup> cotransporter, and induced mechanical allodynia in rats. | 30414958 | 2019 | ||||
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0.360 | Biomarker | phenotype | BEFREE | Intrathecal administration of FLRT3 protein to naive rats induced mechanical allodynia and GluN2B phosphorylation in the spinal cord. | 31346030 | 2019 | ||||
|
0.360 | AlteredExpression | phenotype | BEFREE | Statistical analyses revealed that repeated infusions of IS induced mechanical allodynia and significantly increased the expression of NR2B Tyr-1472 phosphorylation (pNR2B-Y1472) and NR2B Tyr-1252 phosphorylation (pNR2B-Y1252) in the TNC. | 30400767 | 2018 | ||||
|
0.360 | AlteredExpression | phenotype | BEFREE | The NLGN1-targeting siRNA suppressed the synaptic expression of GluN2B-containing NMDAR in CFA-injected mice and meanwhile, attenuated the inflammatory mechanical allodynia and thermal hypersensitivity. | 30049666 | 2018 | ||||
|
0.360 | AlteredExpression | phenotype | BEFREE | This study found mechanical allodynia and thermal hyperalgesia with a remarkable increase in the expression of spinal CXCL13/CXCR5 and IL-17/IL-17RA and trafficking of GluN2B-containing NMDA receptor after remifentanil exposure. | 28359934 | 2017 | ||||
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0.360 | Biomarker | phenotype | BEFREE | Spinal administration of NMDA induces GluN2B-dependent mechanical allodynia, which is prolonged in Arrb2-KO mice and conditional KO mice lacking Arrb2 in presynaptic terminals expressing Nav1.8. | 27538456 | 2016 | ||||
|
0.360 | Biomarker | phenotype | CTD_human | Tyrosine phosphorylation of the N-Methyl-D-Aspartate receptor 2B subunit in spinal cord contributes to remifentanil-induced postoperative hyperalgesia: the preventive effect of ketamine. | 20042082 | 2009 |