Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.360 Biomarker phenotype BEFREE Intrathecal injection of IL-1β induced mechanical allodynia and Cav2.2 upregulation in bilateral L4-6 DRGs of naïve rats, whereas injection of IL-10 substantially prevented mechanical allodynia and Cav2.2 upregulation in L4 DRGs in L5-SNL rats. 29709527 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.360 Biomarker phenotype BEFREE Neuropathic pain is induced by unilateral sciatic chronic constriction injury (CCI), and while enduring relief of light touch sensitivity (mechanical allodynia) in both wild type (WT) and IL-10 KO mice was observed following DM/pDNA-IL-10 co-therapy, transient reversal from allodynia was observed following i.t.DM alone. 29113923 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.360 AlteredExpression phenotype BEFREE Silence of the Bcl3 and Socs3 genes nearly fully reversed IL-10-induced suppression of neuroinflammatory cytokines (but not expression of β-endorphin), although it had no effect on mechanical allodynia. 29928964 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.360 Biomarker phenotype BEFREE These results demonstrate that gp120 causes mechanical hyperalgesia and a peripheral increase in IL-1β and IL-10, and that prior administration of limonene inhibits these changes. 27888114 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.360 Therapeutic phenotype CTD_human Here, using a rat neuropathic pain model induced by repeated systemic paclitaxel injections, we examined whether paclitaxel upregulates proinflammatory cytokine gene expression, and whether these changes and paclitaxel-induced mechanical allodynia can be attenuated by intrathecal IL-1 receptor antagonist (IL-1ra) or intrathecal delivery of plasmid DNA encoding the anti-inflammatory cytokine, interleukin-10 (IL-10). 17174526 2007
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.360 Biomarker phenotype CTD_human Here, using a rat neuropathic pain model induced by repeated systemic paclitaxel injections, we examined whether paclitaxel upregulates proinflammatory cytokine gene expression, and whether these changes and paclitaxel-induced mechanical allodynia can be attenuated by intrathecal IL-1 receptor antagonist (IL-1ra) or intrathecal delivery of plasmid DNA encoding the anti-inflammatory cytokine, interleukin-10 (IL-10). 17174526 2007
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.360 Biomarker phenotype BEFREE Importantly, pDNA-IL-10 gene therapy reversed mechanical allodynia induced by CCI, returning rats to normal pain responsiveness, without additional analgesia. 16949747 2006
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.360 Biomarker phenotype BEFREE IL-10 gene therapy both prevented and reversed thermal hyperalgesia and mechanical allodynia, without affecting basal responses to thermal or mechanical stimuli. 15869510 2005
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.360 Biomarker phenotype CTD_human Cytokine-mediated inflammatory hyperalgesia limited by interleukin-10. 7582491 1995
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.360 Therapeutic phenotype CTD_human Cytokine-mediated inflammatory hyperalgesia limited by interleukin-10. 7582491 1995