| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | Biomarker | phenotype | BEFREE | Our results suggest that TRPA1 acts as a molecular target for ET-1, and sensitization of TRPA1 through ET<sub>A</sub>R-PKA pathway contributes to ET-1-induced mechanical hyperalgesia. | 30990108 | 2020 | ||||
|
0.370 | Biomarker | phenotype | BEFREE | Endothelin-1 elicits directly TRPA1- and TRPV1-mediated mechanical allodynia via both ET<sub>A</sub> and ET<sub>B</sub> receptors on nociceptive fibers. | 29518348 | 2018 | ||||
|
0.370 | AlteredExpression | phenotype | BEFREE | We suggest that the docetaxel-induced mechanical allodynia is mediated by upregulation of TRPA1 in dorsal root ganglion neurons. | 28370084 | 2017 | ||||
|
0.370 | Biomarker | phenotype | BEFREE | In mice, intraplantar injection of HQ at clinically relevant concentrations elicited both acute pain and persistent mechanical hyperalgesia which were almost completely abolished by TRPA1 inhibitors. | 28790335 | 2017 | ||||
|
0.370 | Biomarker | phenotype | BEFREE | Schwann cell TRPA1 generates a spatially constrained gradient of oxidative stress, which maintains macrophage infiltration to the injured nerve, and sends paracrine signals to activate TRPA1 of ensheathed nociceptors to sustain mechanical allodynia. | 29192190 | 2017 | ||||
|
0.370 | Biomarker | phenotype | BEFREE | Tmem100-deficient mice show a reduction in inflammatory mechanical hyperalgesia and TRPA1- but not TRPV1-mediated pain. | 25640077 | 2015 | ||||
|
0.370 | Biomarker | phenotype | CTD_human | Antagonism of the transient receptor potential ankyrin 1 (TRPA1) attenuates hyperalgesia and urinary bladder overactivity in cyclophosphamide-induced haemorrhagic cystitis. | 23523557 | 2013 | ||||
|
0.370 | Biomarker | phenotype | CTD_human | Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation. | 21481532 | 2011 | ||||
|
0.370 | Biomarker | phenotype | CTD_human | Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation. | 18234885 | 2008 | ||||
|
0.370 | Biomarker | phenotype | BEFREE | A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. | 18086313 | 2007 |