Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.300 Biomarker disease CLINGEN Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer. 27978560 2017
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.300 Biomarker disease CLINGEN The depletion of ATM inhibits colon cancer proliferation and migration via B56γ2-mediated Chk1/p53/CD44 cascades. 28093285 2017
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.300 Biomarker disease CLINGEN Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas. 24512911 2014
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.300 Biomarker disease CLINGEN Downregulated Ku70 and ATM associated to poor prognosis in colorectal cancer among Chinese patients. 25368522 2014
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.300 Biomarker disease CLINGEN Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer. 28135145 2017
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.300 Biomarker disease CLINGEN Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN. 23154512 2012
Entrez Id: 580
Gene Symbol: BARD1
BARD1 		0.300 Biomarker disease CLINGEN Expression of oncogenic BARD1 isoforms affects colon cancer progression and correlates with clinical outcome. 22814582 2012
Entrez Id: 580
Gene Symbol: BARD1
BARD1 		0.300 Biomarker disease CLINGEN Expression of an Oncogenic BARD1 Splice Variant Impairs Homologous Recombination and Predicts Response to PARP-1 Inhibitor Therapy in Colon Cancer. 27197561 2016
Entrez Id: 580
Gene Symbol: BARD1
BARD1 		0.300 Biomarker disease CLINGEN Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1. 11498787 2001
Entrez Id: 580
Gene Symbol: BARD1
BARD1 		0.300 Biomarker disease CLINGEN Whole-exome sequencing identifies rare pathogenic variants in new predisposition genes for familial colorectal cancer. 25058500 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.300 Biomarker disease CLINGEN Identification of seven novel germline mutations in the human E-cadherin (CDH1) gene. 17221870 2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.300 Biomarker disease CLINGEN Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer. 10072428 1999
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.300 Biomarker disease CLINGEN Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells. 10051639 1999
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.300 Biomarker disease CLINGEN E-cadherin germline mutations in familial gastric cancer. 9537325 1998
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.300 Biomarker disease CLINGEN Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred. 11968083 2002
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.300 Biomarker disease CLINGEN Loss of CDH1 (E-cadherin) expression is associated with infiltrative tumour growth and lymph node metastasis. 26742007 2016
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B 		0.300 Biomarker disease CLINGEN The murine gene p27Kip1 is haplo-insufficient for tumour suppression. 9823898 1998
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B 		0.300 Biomarker disease CLINGEN Tumorigenesis in p27/p53- and p18/p53-double null mice: functional collaboration between the pRb and p53 pathways. 15584024 2005
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B 		0.300 Biomarker disease CLINGEN p27kip1 deficiency impairs G2/M arrest in response to DNA damage, leading to an increase in genetic instability. 17954563 2008
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B 		0.300 Biomarker disease CLINGEN p27kip1 Regulates cdk2 activity in the proliferating zone of the mouse intestinal epithelium: potential role in neoplasia. 17631145 2007
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B 		0.300 Biomarker disease CLINGEN Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases. 9736017 1998
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B 		0.300 Biomarker disease CLINGEN Comparative effects of overexpression of p27Kip1 and p21Cip1/Waf1 on growth and differentiation in human colon carcinoma cells. 9926925 1999
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B 		0.300 Biomarker disease CLINGEN Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice. 12086850 2002
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B 		0.300 Biomarker disease CLINGEN Whole-exome sequencing identifies rare pathogenic variants in new predisposition genes for familial colorectal cancer. 25058500 2015
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.300 Biomarker disease CLINGEN The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population. 18996005 2009