Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.090 Biomarker disease BEFREE Coumarin- Fatty Acid Conjugates as Potential ERα/AKT-1 Antagonists for ER Positive Breast Cancer. 31746305 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.090 Biomarker disease BEFREE These results underscore the critical role of estrogen-ERα as a modulator of the PI3K/AKT/mTOR signaling pathway in ER-positive breast cancer cells. 31189691 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.090 AlteredExpression disease BEFREE Estrogen receptor alpha drives mTORC1 inhibitor-induced feedback activation of PI3K/AKT in ER+ breast cancer. 29507656 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.090 GeneticVariation disease BEFREE Clinical significance of plasma cell-free DNA mutations in PIK3CA, AKT1, and ESR1 gene according to treatment lines in ER-positive breast cancer. 29482551 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.090 GeneticVariation disease BEFREE Both assays are employed at centralized testing laboratories operating according to quality standards for prospective identification of the AKT1 E17K mutation in ER+ breast cancer patients in the context of a clinical trial evaluating the AKT inhibitor AZD5363 in combination with endocrine (fulvestrant) therapy. 28472036 2017
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.090 GeneticVariation disease BEFREE We propose a randomized clinical trial to test whether the 31-gene AKT module could be used to identify estrogen receptor positive breast cancer patients who may benefit from therapy targeting the PI3K/AKT/mTOR signaling axis. 25886003 2015
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.090 Biomarker disease BEFREE Our results thus indicated that ER-α36-mediated antiestrogen signaling such as the PI3K/AKT plays an important role in antiestrogen resistance of ER-positive breast cancer stem/progenitor cells. 25158023 2014
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.090 Biomarker disease BEFREE BTG2 inhibits the expression of HER ligands and promotes AKT activation, which plays an essential role in the tamoxifen resistance of estrogen receptor (ER)-positive breast cancer. 24698107 2014
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.090 Biomarker disease BEFREE Knockdown of the tumor suppressor phosphatase Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) with shRNA in three estrogen receptor (ER)-positive breast cancer cell lines resulted in increased phosphatidylinositol-3 kinase (PI3K) and AKT activities, resistance to tamoxifen and fulvestrant, and hormone-independent growth. 19435893 2009