Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE PD-1 and PD-L1 expression was present in biopsy samples (47% and 53%, respectively), absent in resections, and present in metastases (40% and 47%). 31842180 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE Meanwhile, we also confirmed the down-regulation of PD-L1 in osteosarcoma in response to PDT and 3-MA treatment, which significantly inhibited tumor growth in a model of tumor metastasis. 30448697 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE This data brings new light to future treatment using targeted therapy to EGFR or CD274 to include retesting such biomarkers in recurrence and lymph nodes metastases. 31844270 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE PD-L1 TPS scores were not significantly different across a range of distant metastatic sites nor between metastases in paired samples. 31097091 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE In survival analyses, a significantly better overall survival was observed for patients with PD-L1 negative primary breast tumors that developed PD-L1 positive distant metastases (HR 3.013, CI 1.201-7.561, p = 0.019). 30547271 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE PD-1/PD-L1 pathway was expressed in MTC patients and was significantly correlated with the distant metastases at surgery, which may shed light on PD-1/PD-L1 as a promising therapeutic target in MTC. 30528043 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE A positive correlation between PD-L1 negativity and mucinous and poorly cohesive carcinoma could be shown (p = 0.043), while no association existed for either gender, T-stage, N-stage, grading, surgical resection status, neoadjuvant therapy, distant metastases, lymphovascular or perineural invasion. 31043352 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE PD-L1 positivity was reduced in lymph nodes by 15.2% (5/33) and in distant metastases by 21.4% (3/14). 31415379 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE PD-L1 positivity was observed in 33% and 39% of primary melanomas and matched metastases, respectively, with, however, poor concordance between the primary and the matched metastatic site (κ = 0.283). 31625630 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE All patients receiving a single-agent ICI (cytotoxic T-lymphocyte-associated protein 4 [CTLA-4] or programmed death(ligand)1 [PD(L)-1] inhibitors) for the standard treatment of a locally advanced or metastatic cancer were included in this retrospective multicentric series. 31590080 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE Until now, anti-PD-L1 immunohistochemistry (IHC) on tissue sections has been the only validated companion diagnostic test for first-line immunotherapy for advanced and metastatic cancer, notably non-small-cell lung cancer (NSCLC). 31228184 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE The concordance of PD-L1 positivity between EBUS-TBNA and other specimens was moderate; κ = 0.63 for EBUS-TBNA vs. TBB, κ = 0.68 for EBUS-TBNA vs. resected primary tumors, and κ = 1.0 for EBUS-TBNA vs. resected metastases. 31319982 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE Patients with metastatic cancer (<i>n</i> = 198) were analyzed by flow cytometry for DC-HIL or PDL1 expression on blood CD14<sup>+</sup>HLA-DR<sup>no/lo</sup> MDSCs. 30049749 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE Expression of PD-L1 was assessed by immunochemistry using the SP263 clone in 107 resected primary NSCLCs and their nodal metastases. 31320000 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE Moreover, in vivo anti-tumor studies reveal that Au@Pt-LM<sup>D</sup>P nanosystem can effectively eliminate primary tumors via PTT, and further stimulate the activation of cytotoxic T lymphocytes by PD-L1 immune checkpoint blockage, result in inhibiting the growth of distal tumors and alleviating tumor metastasis. 31252039 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE PD-L1 fidelity between primary bladder tumors and nodal metastases was observed in >75% of cases in this study. 31201825 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE PD-L1 expression in cancer cells correlated significantly with tumor size, and the presence of regional metastases (P < 0.01). 30821864 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE Of note, however, PD-L1 expression in the metastases was higher than that in the primary tumors. 30962002 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE We investigated the immunohistochemical profile of CLDN18, p53, p16, E-cadherin, MSH2, MSH6, MLH1, PSM2, HER2, and PDL-1 in a large series of 523 primary gastric carcinomas (GCs; n = 408) and gastro-oesophageal carcinomas (GECs; n = 115) and 135 matched and synchronous nodal metastases. 31235864 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE Four parathyroid carcinoma cases had programmed death-ligand 1 H scores ≥1 associated with CD3+ and CD8+ tumor cell density; 2 of them had distant metastases. 30033186 2018
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE By further combining with the checkpoint blockade adjusted by programmed death ligand 1 (PD-L1) antibody, the Fe<sub>3</sub>O<sub>4</sub>-R837 SP-involved PTT cannot only eliminate the primary tumors but also prevent tumor metastasis to lungs/liver. 29878757 2018
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE Noninvasive Imaging of Immune Checkpoint Ligand PD-L1 in Tumors and Metastases for Guiding Immunotherapy. 28707500 2018
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE Here, we determined PD-L1 protein expression by immunohistochemistry using a validated PD-L1-specific antibody (SP263) in a large and representative cohort of primary prostate cancers and prostate cancer metastases. 29577933 2018
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE Combined with immune checkpoints blockade therapy by programmed death 1 (PD-1) antibody, the dual inhibition of the PD-1/PD-L1 axis elicits significant immune response and presents a robust effect in lengthening tumor recurrent time and inhibiting tumor metastasis. 29882235 2018
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE In positive cases, high PD-L1 expression (>50% cells) was detected in 34.1% primary and 46.7% metastases. 29271413 2018