Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 GeneticVariation group BEFREE Deletion or mutation of at least one PTEN allele has been reported to occur in 20% to 40% of localized PCa and up to 60% of metastases. 31111513 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 GeneticVariation group BEFREE We have previously demonstrated a significant correlative relationship between PTEN deletion and ERG rearrangement, both in the development of clinically localized prostate cancers and metastases. 30291535 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 Biomarker group BEFREE microRNA-19a-3p promotes tumor metastasis and chemoresistance through the PTEN/Akt pathway in hepatocellular carcinoma. 30021351 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 Biomarker group BEFREE Collectively, our data identified a tumor inducer, SYNJ2BP, which could activate the PI3K/AKT/GSK3β/SNAI1 signaling pathway through the lysosome-mediated degradation of PTEN, and promote both EMT and tumor metastasis during the progression of breast cancer. 29163781 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 AlteredExpression group BEFREE Among patients without distant metastases (n = 282), a high pretreatment PTEN mRNA level was associated with inferior relapse-free (RFS; p = 0.001) and disease-specific survival (DSS; p = 0.003). 28213783 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 AlteredExpression group BEFREE Concordant analysis of KRAS, BRAF, PIK3CA mutations, and PTEN expression between primary colorectal cancer and matched metastases. 25639985 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 Biomarker group BEFREE Bioinformatics analysis combined with tumor metastasis PCR array showed that matrix metalloproteinase 2 (MMP2) and PTEN could be important target genes of miR-29b. 26063204 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 Biomarker group BEFREE PTEN loss in metastases appears to be associated with response to bevacizumab-based therapy. 24980447 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 Biomarker group BEFREE The variables associated with a shorter time to metastases/recurrence were gastrointestinal histology (P = 0.004), APC (P = 0.008), PTEN (P = 0.026) and TP53 (P = 0.044) alterations. 25928476 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 Biomarker group BEFREE Except for true de novo mutations in 4 cases (affecting SYNE1, CTNNB1, TP53, and PTEN), all remaining cases (84.4%) shared the genetic lesions of the primary tumors with all investigated metastases irrespective of the site of metastasis or time lapse between primary tumor resection and the occurrence of metastatic spread. 25786087 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 GeneticVariation group BEFREE Detection of certain molecular markers such as deletion of 1p and 19q chromosomal arms, hypermethylation of MGMT promoter, and characteristic PTEN exon mutations may help differentiate subtypes which are more prone to extracranial metastases. 24447608 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 AlteredExpression group BEFREE PTEN expression in CAFs in distant metastases was lost in 11 of 181 CRC patients (6.1%), which was associated with a worse prognosis. 24642707 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 PosttranslationalModification group BEFREE To our knowledge, this is the first report to show the presence of PTEN promoter CpG hypermethylation in ESCC and its association with tumor metastasis. 23980519 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 Biomarker group BEFREE Thus, for the first time, we provided convincing evidence that upregulation of miR-494 was associated with tumor aggressiveness and tumor metastasis and promoted cell migration and invasion by targeting PTEN gene in colorectal cancer, and miR-494 is an independent prognostic marker for colorectal cancer patients. 25270723 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 GeneticVariation group BEFREE Neck node metastases also correlate with copy number gain of EGFR (p = .004) and HER2, aberration of MET, and deletion of PTEN (p < .001 each). 23780687 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 Biomarker group BEFREE High-expression of DJ-1 and loss of PTEN associated with tumor metastasis and correlated with poor prognosis of gastric carcinoma. 24155657 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 GeneticVariation group BEFREE PTEN mutations were associated with nodal metastases. 23728071 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 AlteredExpression group BEFREE PIK3CA exon 9 mutations in primary tumors and loss of PTEN nuclear expression in metastases correlated with KRAS mutations. 22936063 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 AlteredExpression group BEFREE In contrast, AKT, p-AKT, and PTEN expression was identical in monolayer cultures derived from melanoma brain and extracerebral metastases. 24133630 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 AlteredExpression group BEFREE Proportional hazard models were used to assess PTEN expression and its interaction with IGF-IR, in relation to lethal prostate cancer (cancer-specific death or distant metastases). 23983239 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 Biomarker group BEFREE On the other hand, the immunohistochemical analysis of EGFR, PTEN and pAKT showed a much higher degree of discordance between primaries and related metastases. 22229245 2012
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 GeneticVariation group BEFREE Multivariate analysis determined that HER2 overexpression was associated with an increasing risk of developing metastases (OR: 4.3; 95%CI: 1.2-15.9; p: 0.03) while PTEN overexpression was associated with lower risk (OR: 0.1; 95%CI: 0.1, 1.0; p: 0.05). 23464451 2012
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 GeneticVariation group BEFREE PTEN deletion was correlated with nodal (8 of 122 cases (6.6%); p=0.041) and distant metastases (4 of 19 (21.1%); p<0.001). 22639407 2012
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 Biomarker group BEFREE We quantified PTEN in 135 clear cell renal cell carcinomas (ccRCC) by Western blot analysis and found statistically significant lower PTEN expression in patients who died, usually caused by metastases, within 5 years after surgery, compared to those surviving this time period. 21206972 2011
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 Biomarker group BEFREE There were five cases of PTEN loss and eight cases of PTEN gain from primary tumors to metastases (26% discordance). 21490305 2011