Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker group BEFREE In 4T1-luc metastatic breast cancer model in mice, Sap-EGFR/CD44-NGs exhibited significant inhibition of tumor metastasis to lung at a small dose of 3.33 nmol Sap equiv./kg. 30699364 2019
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 AlteredExpression group BEFREE Surprisingly, EPR and Dox combination significantly down-regulated the CD44 receptor expression which is the main contributing factor of tumor metastasis. 31086900 2019
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker group BEFREE A correlation with EMT was supported by an increase in CD44 in vertebral metastases and parenchymal metastases. 31064271 2019
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker group BEFREE Inducible formation of leader cells driven by CD44 switching gives rise to collective invasion and metastases in luminal breast carcinomas. 31417182 2019
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker group BEFREE In contrast, loss of CD44 resulted in significant increase of tumor burden at several locoregional sites, including liver, and unleashed distant metastases to the thoracic cavity. 31147393 2019
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker group BEFREE To test whether endothelial cells (ECs) associated with lung metastases express a distinct gene expression program that promotes metastatic growth, we isolated CD31<sup>+</sup>/CD45<sup>-</sup> cells from lung mammary cancer metastases for RNA sequencing and found CD44 upregulation. 31722193 2019
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker group BEFREE Preoperative assessment of CD44-mediated depth of invasion as predictor of occult metastases in early oral squamous cell carcinoma. 30561155 2019
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker group BEFREE Immunohistochemical staining and flow cytometry of CD44 and E-cadherin were compared in primary tumor, metastasis, and cell cultures. 29693014 2018
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker group BEFREE CDH6, CDH11 and CD44 serve important roles in OSCC metastasis and the combined use of these factors as biomarkers may improve the accuracy of the prediction of cancer metastases and prognosis. 29805672 2018
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker group BEFREE We further demonstrated, for the first time, that the degree of hypoxia-induced CSC-sphere formation (CD44(+) subpopulation) in vitro and of tumor metastasis/dissemination in vivo were markedly suppressed by knocking down Id2 expression. 26965643 2016
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker group BEFREE Mixed co-injections of TME-enriched CD44+/CD24low/- and CD44+/β1+ sub-populations generated metastases populated mostly by CD44+/CD24low/--derived cells. 27835603 2016
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker group BEFREE CD44 is a well-established cancer stem cell marker playing a crucial role in tumor metastasis, recurrence and chemo-resistance. 27521214 2016
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker group BEFREE We previously demonstrated that Glypican-5 (GPC5), one of the members of heparan sulfate proteoglycan, was a novel tumor metastasis suppressor in lung adenocarcinoma (LAC). 27806326 2016
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker group BEFREE Furthermore, deguelin-treated tumors showed decreased the tumor metastasis related genes such as CD44, MMP2 and MMP9 at protein and mRNA levels and the content of CEA, SCC, NSE, CYFAR21-1. 26884827 2015
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker group BEFREE CD44 is a widely known cancer stem cells marker in various cancers and validated to function in tumor growth, survival and tumor metastasis. 26540347 2015
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker group BEFREE CD44⁻CD24⁺ CSCs-like displayed a distinct bone tropism signature that was enriched in genes that discriminate bone metastases of breast cancer from metastases at other organs. 23801032 2013
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker group BEFREE These findings support the thesis of the role of CD44s glycoprotein in the invasive growth potential of neoplastic cells and suggest that its expression could be taken into consideration in the therapeutic approaches targeting metastases. 23445749 2013
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker group BEFREE Cell surface biomarker CD44 plays an important role in breast cancer cell growth, differentiation, invasion, angiogenesis and tumour metastasis. 23940692 2013
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 AlteredExpression group BEFREE We hypothesize that a developed cancer-targeted delivery system that combines CD44 siRNA with paclitaxel would successfully deliver its payload inside cancer cells, effectively induce cell death, and prevent metastases. 24036854 2013
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker group BEFREE Similarly, the expression of hyaluronan synthases 1-2 and CD44 receptor was decreased in the metastases compared to the primary melanomas. 23560496 2013
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 AlteredExpression group BEFREE Targeted inhibition of lipogenic enzymes abolished expression of CD44, a transmembrane protein associated with metastases in several cancers including CRC. 22266115 2012
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker group BEFREE In addition, 2-D DIGE and HPLC/MS-MS of HER2(+)/CD44(+)/CD24(-/low) versus HER2(-)/CD44(+)/CD24(-/low) BCSCs reported a unique HER2-associated protein profile including effectors involved in tumor metastasis, apoptosis, mitochondrial function, and DNA repair. 23091114 2012
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 AlteredExpression group BEFREE When inoculated subcutaneously into NOD/SCID animals, the CD44 negative cells were capable of tumor formation and organ infiltration, clearly demonstrating an inverse correlation of CD44 expression and neuroblastoma metastases formation. 21424816 2011
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker group BEFREE CD44 is a cell-surface glycoprotein involved in many cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis and tumor metastasis, suggesting that CD44 may play an important role in breast cancer development. 21804359 2011
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker group BEFREE Specifically, P-glycoprotein and CD44 have been characterized and are known to be determinants of multidrug resistance (MDR) and metastases. 16061646 2005