Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 AlteredExpression disease BEFREE Cell-mediated delivery of VEGF modified mRNA enhances blood vessel regeneration and ameliorates murine critical limb ischemia. 31425721 2019
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 Biomarker disease BEFREE Enrichment of vascular endothelial growth factor secreting mesenchymal stromal cells enhances therapeutic angiogenesis in a mouse model of hind limb ischemia. 30879964 2019
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 Biomarker disease BEFREE Biodegradable Carriers for Delivery of VEGF Plasmid DNA for the Treatment of Critical Limb Ischemia. 28848442 2017
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 Biomarker disease BEFREE Loss of osteoglycin promotes angiogenesis in limb ischaemia mouse models via modulation of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 signalling pathway. 28069703 2017
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 Biomarker disease BEFREE Effective sEVs (e-sEVs) also improved vascular remodeling and prevented muscle damage in a mouse model of acute hind limb ischemia. e-sEV angiogenic proteomic and transcriptomic analyses show a positive correlation with matrix-metalloproteinase activation and extracellular matrix organization, cytokine and chemokine signaling pathways, Insulin-like Growth Factor and platelet pathways, and Vascular Endothelial Growth Factor signaling. 28811546 2017
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 Biomarker disease BEFREE Additionally, taking into account numerous experimental and clinical data demonstrating rather insufficient therapeutic potential of VEGF, we called into question the role of this protein in limb ischemia and vessel regeneration. 27620809 2016
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 Biomarker disease BEFREE Several studies of stem cell-based gene therapy have indicated that long-lasting regeneration following vessel ischemia may be stimulated through VEGFA gene therapy and/or MSC transplantation for reduction of ischemic injury in limb ischemia and heart failure. 25860916 2015
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 Biomarker disease BEFREE Pre-clinical studies and Phase I clinical trials using VEGF and fibroblast growth factor (FGF) demonstrated promising results; however, more rigorous Phase II and III clinical trials failed to demonstrate benefits for CLI patients. 25633211 2015
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 AlteredExpression disease BEFREE These results suggest that E6E7-MSCs increase the ability to secrete angiogenic factors via AKT activation, and E6E7-CM is abundant in IL-1β and VEGFA levels and thereby increases the ability to improve blood perfusion and prohibit muscle loss or fibrosis in a mouse limb ischemia model. 24786397 2014
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 Therapeutic disease RGD The therapeutic effect of vascular endothelial growth factor gene- or heme oxygenase-1 gene-modified endothelial progenitor cells on neovascularization of rat hindlimb ischemia model. 23562340 2013
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 Biomarker disease BEFREE A hind limb ischemia model was generated in nude mice, and VEGF(165) gene-transfected EPCs were transplanted intramuscularly into the ischemic limbs. 22921925 2012
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 AlteredExpression disease BEFREE Treatment of mouse limb ischemia with an integrative hypoxia-responsive vector expressing the vascular endothelial growth factor gene. 22470498 2012
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 AlteredExpression disease BEFREE FACS-purified myoblasts producing controlled VEGF levels induce safe and stable angiogenesis in chronic hind limb ischemia. 21418520 2012
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 Biomarker disease BEFREE MSCs engineered to overexpress VEGF strongly induced the migration of endothelial cells and enhanced blood flow restoration in a xenograft model of hind limb ischemia. 21898687 2011
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 GeneticVariation disease BEFREE The study aims to use cholesterol (Chol) + DOTAP liposome (CD liposome) based human vascular endothelial growth factor-165 (VEGF(165)) gene transfer into skeletal myoblasts (SkMs) for treatment of acute hind limb ischaemia in a rabbit model. 18681907 2010
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 Biomarker disease BEFREE VEGF-inducing agents have also been used experimentally to induce angiogenesis in patients with critical limb ischemia. 18799497 2009
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 Biomarker disease BEFREE Treatment with intramuscular vascular endothelial growth factor gene compared with placebo for patients with diabetes mellitus and critical limb ischemia: a double-blind randomized trial. 16776576 2006
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 Biomarker disease BEFREE Our results indicate that NOS1177D gene delivery to the ischemic skeletal muscle can be efficient to reverse critical limb ischemia in pathological settings, which are refractory to treatments with a single growth factor, such as vascular endothelial growth factor. 16642030 2006
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 Biomarker disease BEFREE We have investigated whether telomerase contributes to tissue regeneration following hind limb ischemia and vascular endothelial growth factor 165 (VEGF(165)) treatment. 15687494 2005
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 AlteredExpression disease BEFREE Using murine limb ischemia as a tumor-free assay system, we demonstrated that p70S6K inhibitor rapamycin (RAPA) targets mesenchymal cells to shut down the sustained expression of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), via silencing of the PDGFRalpha-p70S6K pathway. 15059936 2004
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 Biomarker disease BEFREE Also, we recently showed the superior therapeutic potential of basic fibroblast growth factor (bFGF/FGF-2) boosted by the recombinant Sendai virus (SeV) for severe limb ischemia compared with that of vascular endothelial growth factor. 12623787 2003
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 Biomarker disease BEFREE Adenoviral-mediated gene transfer of vascular endothelial growth factor in critical limb ischemia: safety results from a phase I trial. 12866606 2003
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 AlteredExpression disease BEFREE Intramuscular injection of SeV strongly boosted FGF-2, resulting in significant therapeutic effects for limb salvage with increased blood perfusion associated with enhanced endogenous VEGF expression in murine models of critical limb ischemia. 12016262 2002
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 Biomarker disease BEFREE To investigate the effects of vascular endothelial growth factor gene therapy on ischemic neuropathy in patients with critical limb ischemia. 11346371 2001
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.300 Biomarker disease BEFREE Recent human clinical trials have shown that injection of naked DNA encoding vascular endothelial growth factor promotes collateral vessel development in patients with critical limb ischemia or chronic myocardial ischemia. 11325212 2001