Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7173
Gene Symbol: TPO
TPO 		0.050 GeneticVariation disease BEFREE PD patients showed a weakened cerebellar dentate nucleus (DN) functional coupling in the posterior cingulate cortex (PCC) and inferior parietal lobe compared with MSA-P or controls. 28848423 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		0.040 AlteredExpression disease BEFREE PD significantly increased the expression of TGF-β1, VEGF and ALK5 protein in peritoneal tissues. 30887626 2019
Entrez Id: 6606
Gene Symbol: SMN1
SMN1 		0.010 AlteredExpression disease BEFREE PD significantly increased fibrosis (Masson staining) and the expression of fibroblast marker α-SMA in peritoneal tissues. 30887626 2019
Entrez Id: 6607
Gene Symbol: SMN2
SMN2 		0.010 AlteredExpression disease BEFREE PD significantly increased fibrosis (Masson staining) and the expression of fibroblast marker α-SMA in peritoneal tissues. 30887626 2019
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.040 Biomarker disease BEFREE APOE genotyping was available for 107 PD patients (26 with and 81 without dementia) and 4,805 non-PD control subjects. 10746597 2000
Entrez Id: 1312
Gene Symbol: COMT
COMT 		0.040 GeneticVariation disease BEFREE COMT polymorphism, considered alone, showed no correlation with PD risk; however, a significant synergistic enhancement was found in PD patients harboring both the COMT(L) and MAOB G genotypes. 11171904 2001
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA 		0.030 Biomarker disease BEFREE Vascular endothelial growth factor (VEGF) was recently found in peritoneal effluents of peritoneal dialysis (PD) patients. 11849398 2002
Entrez Id: 4018
Gene Symbol: LPA
LPA 		0.010 GeneticVariation disease BEFREE Lipoprotein(a) level and apo(a) phenotype are associated with PD patient mortality. 12322821 2003
Entrez Id: 4137
Gene Symbol: MAPT
MAPT 		0.660 Biomarker disease BEFREE Tau protein was implicated in AD pathophysiology and the tau gene haplotype is probably connected with sporadic late-onset Parkinson's disease (PD). 12932819 2003
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2 		0.200 GeneticVariation disease BEFREE LRRK2 G2019S is a common mutation in Spanish patients with late-onset Parkinson's disease. 16298482 2006
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		0.400 GeneticVariation disease BEFREE Parkin gene variations in late-onset Parkinson's disease: comparison between Norwegian and German cohorts. 16367892 2006
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2 		0.200 GeneticVariation disease BEFREE LRRK2 mutation carriers generally simulate late onset Parkinson's disease and present with the usual typical clinical features. 19804413 2009
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2 		0.200 GeneticVariation disease BEFREE LRRK2 sequencing revealed a novel co-segregating missense mutation in exon 36 (c.5281A>C; p.S1761R) located within a highly conserved region of the COR [C-terminal of ROC (Ras of complex proteins)] domain wherein it could deregulate LRRK2 kinase activity by modifying ROC-COR dimer stability. p.S1761R was present in a late-onset Parkinson's disease family and in 2 unrelated Parkinson's disease subjects, but not in 2491 healthy controls. 22038903 2012
Entrez Id: 1401
Gene Symbol: CRP
CRP 		0.090 GeneticVariation disease BEFREE CRP gene -717AG or GG genotypes is associated with cardiovascular benefit to Chinese PD patients with cholesterol levels of 200 mg/dl or greater. 22241816 2012
Entrez Id: 148979
Gene Symbol: GLIS1
GLIS1 		0.010 GeneticVariation disease BEFREE GLIS1 rs797906: an increased risk factor for late-onset Parkinson's disease in the Han Chinese population. 22759478 2012
Entrez Id: 51330
Gene Symbol: TNFRSF12A
TNFRSF12A 		0.010 AlteredExpression disease BEFREE Fn14 expression was also analyzed in peritoneal biopsies from PD patients. 24599047 2014
Entrez Id: 1490
Gene Symbol: CCN2
CCN2 		0.020 AlteredExpression disease BEFREE CCN2 protein levels were significantly higher in peritoneal effluent of EPS patients compared to levels in dialysate of PD patients (12.0 ± 4.5 vs. 0.91 ± 0.92 ng/ml, P < 0.01), while plasma CCN2 levels were not increased. 25384022 2014
Entrez Id: 26058
Gene Symbol: GIGYF2
GIGYF2 		0.030 GeneticVariation disease BEFREE GIGYF2 mutation in late-onset Parkinson's disease with cognitive impairment. 26134514 2015
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.040 Biomarker disease BEFREE Interleukin-6 (IL-6) is a vital inflammatory factor in the peritoneal cavity of peritoneal dialysis (PD) patients. 26869278 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9 		0.010 Biomarker disease BEFREE MMP9 is a potential biomarker for peritoneal membrane injury and is a therapeutic target to protect the peritoneal membrane in PD patients. 27190383 2017
Entrez Id: 1814
Gene Symbol: DRD3
DRD3 		0.020 GeneticVariation disease BEFREE DRD3 rs6280" genes_norm="1814">p.Ser9Gly (rs6280) CT genotype is associated with ICD in Indian PD patients and this association is novel. 27325396 2016
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.100 Biomarker disease BEFREE α-Synuclein plays important roles in the development of Parkinson's disease (PD) pathologies. 27546826 2016
Entrez Id: 4129
Gene Symbol: MAOB
MAOB 		0.030 Biomarker disease BEFREE Monoamine oxidase type B (MAO-B) inhibitors exhibit neuroprotective effects in preclinical models of PD but clinical trials have failed to convincingly demonstrate disease modifying benefits in PD patients. 27911341 2017
Entrez Id: 83636
Gene Symbol: C19orf12
C19orf12 		0.010 Biomarker disease BEFREE C19orf12 has previously been screened in PD patients in only one study, and to the best of our knowledge neither gene has ever been screened in a PD cohort from a Middle East population. 28365006 2017
Entrez Id: 2629
Gene Symbol: GBA
GBA 		0.690 AlteredExpression disease BEFREE β-glucocerebrosidase specific activity was also decreased in noncarrier PD patients versus controls (-25%, P < 0.001). 28843015 2017