Gene: KIT ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 Biomarker disease CTD_human Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression. 27793025 2016
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 GeneticVariation disease BEFREE KIT mutations, compared with PDGFRA mutations and wild type, represent a poorer prognostic marker in high risk or malignant GISTs. 24674052 2014
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 SomaticCausalMutation disease ORPHANET Succinate dehydrogenase deficiency in pediatric and adult gastrointestinal stromal tumors. 23730622 2013
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 Biomarker disease CTD_human Proapoptotic activity of bortezomib in gastrointestinal stromal tumor cells. 20028860 2010
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 GeneticVariation disease BEFREE Tumors with deletion/insertion mutations affecting codons 557/558 of the KIT gene seem to represent a distinct subset of malignant GISTs. 18350628 2008
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 Biomarker disease CLINGEN Rectal gastrointestinal stromal tumors associated with a novel germline KIT mutation. 18183595 2008
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 Biomarker disease CLINGEN A mouse model of a human multiple GIST family with KIT-Asp820Tyr mutation generated by a knock-in strategy. 18098338 2008
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 Biomarker disease CLINGEN Familial gastrointestinal stromal tumors caused by the novel KIT exon 17 germline mutation N822Y. 18724244 2008
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 Biomarker disease CLINGEN Imatinib in the management of multiple gastrointestinal stromal tumors associated with a germline KIT K642E mutation. 17824795 2007
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 Biomarker disease CTD_human Flavopiridol targets c-KIT transcription and induces apoptosis in gastrointestinal stromal tumor cells. 16740725 2006
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 Biomarker disease CLINGEN Novel germline mutation of KIT associated with familial gastrointestinal stromal tumors and mastocytosis. 16143141 2005
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 Biomarker disease CLINGEN A knock-in mouse model of gastrointestinal stromal tumor harboring kit K641E. 16061643 2005
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 GeneticVariation disease BEFREE C-kit gene mutations occur preferentially in malignant GISTs and might be a clinically useful adjunct marker in the evaluation of GISTs and can help to differentiate GISTs from other mesenchymal tumors of gastrointestinal tract, such as smooth muscle tumors, schwannomas, etc. 15112348 2004
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 Biomarker disease CLINGEN Pleomorphic characteristics of a germ-line KIT mutation in a large kindred with gastrointestinal stromal tumors, hyperpigmentation, and dysphagia. 14977822 2004
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 Biomarker disease CLINGEN Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase. 12754375 2003
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 GeneticVariation disease BEFREE Mutations of KIT are common in malignant GISTs and lead to constitutional activation of tyrosine kinase function, which causes cellular proliferation and resistance to apoptosis. 14515284 2003
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 Biomarker disease CLINGEN Familial gastrointestinal stromal tumors associated with dysphagia and novel type germline mutation of KIT gene. 11984533 2002
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 GeneticVariation disease BEFREE Several reports have suggested that KIT gene mutations are more common in malignant GISTs than in benign lesions, and it has been proposed that mutations in exon 11 of KIT are a negative prognostic factor. 12000708 2002
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 Biomarker disease CLINGEN Familial gastrointestinal stromal tumor with hyperpigmentation: association with a germline mutation of the c-kit gene. 11208730 2001
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 Biomarker disease CLINGEN Germline mutation in the juxtamembrane domain of the kit gene in a family with gastrointestinal stromal tumors and urticaria pigmentosa. 11505412 2001
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 GeneticVariation disease BEFREE KIT mutations were seen in four of five malignant GISTs with loss of chromosome 9, but only in one of four malignant tumors with loss of chromosome 1. 11454425 2001
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 GeneticVariation disease BEFREE Mutation in the c-kit gene is associated with aggressive features and poor prognosis, and malignant GISTs frequently have mutations in the c-kit gene. 11005253 2000
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 GermlineCausalMutation disease ORPHANET Germline-activating mutation in the kinase domain of KIT gene in familial gastrointestinal stromal tumors. 11073817 2000
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 Biomarker disease CLINGEN Germline-activating mutation in the kinase domain of KIT gene in familial gastrointestinal stromal tumors. 11073817 2000
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.670 Biomarker disease CLINGEN Familial gastrointestinal stromal tumours with germline mutation of the KIT gene. 9697690 1998