Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2658
Gene Symbol: GDF2
GDF2
0.190 AlteredExpression disease BEFREE Here we determine the functional impact of GDF2 mutations and characterised plasma BMP9 and BMP10 levels in patients with idiopathic PAH. 31661308 2020
Entrez Id: 2658
Gene Symbol: GDF2
GDF2
0.190 Biomarker disease BEFREE Our data obtained in human pulmonary endothelial cells derived from controls and pulmonary arterial hypertension patients indicate that BMP9 can affect the balance between endothelin-1, apelin, and adrenomedullin. 30636542 2019
Entrez Id: 2658
Gene Symbol: GDF2
GDF2
0.190 Biomarker disease BEFREE We also confirmed the genome-wide association of recently reported growth differentiation factor (GDF2) with IPAH and further implicate T-box 4 (TBX4) with child-onset PAH. 31727138 2019
Entrez Id: 2658
Gene Symbol: GDF2
GDF2
0.190 Biomarker disease BEFREE BMP9 is a sensitive and specific biomarker of PoPH, predicting transplant-free survival and the presence of PAH in liver disease. 30312106 2019
Entrez Id: 2658
Gene Symbol: GDF2
GDF2
0.190 Biomarker disease BEFREE Case-control analyses reveal significant overrepresentation of rare variants in ATP13A3, AQP1 and SOX17, and provide independent validation of a critical role for GDF2 in PAH. 29650961 2018
Entrez Id: 2658
Gene Symbol: GDF2
GDF2
0.190 Biomarker disease BEFREE Selective enhancement of endothelial BMPR2 with BMP9 reverses pulmonary arterial hypertension. 26801773 2016
Entrez Id: 2658
Gene Symbol: GDF2
GDF2
0.190 Biomarker disease BEFREE Therefore, our findings demonstrated that missense mutations of ACVRL1 identified in the present study significantly affected the bone morphogenetic protein 9 (BMP-9) pathway, implicating PAH pathogenesis. 27316748 2016
Entrez Id: 2658
Gene Symbol: GDF2
GDF2
0.190 AlteredExpression disease BEFREE Taken together, the data identify MxA as a novel stimulator of BMP4 and BMP9 transcriptional signaling, and suggest it to be a candidate IFN-α-inducible mechanism that might have a protective role against development of PAH and other vascular diseases. 27875556 2016
Entrez Id: 2658
Gene Symbol: GDF2
GDF2
0.190 Biomarker disease BEFREE Administration of BMP9 reversed established PAH in these mice, as well as in two other experimental PAH models, in which PAH develops in response to either monocrotaline or VEGF receptor inhibition combined with chronic hypoxia. 26076038 2015
Entrez Id: 2658
Gene Symbol: GDF2
GDF2
0.190 Biomarker disease HPO