Gene: ACE2 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 59272
Gene Symbol: ACE2
ACE2 		0.060 Biomarker disease BEFREE <b>Conclusions:</b> Our findings suggest that ACE2 activation attenuates pulmonary vascular remodeling by inducing pulmonary arterial cell apoptosis via Hippo/Yap signaling during the development of PAH. 30806090 2019
Entrez Id: 59272
Gene Symbol: ACE2
ACE2 		0.060 AlteredExpression disease BEFREE After confirming reduced plasma ACE2 activity in human PAH, five patients were enrolled in the trial. 29903860 2018
Entrez Id: 59272
Gene Symbol: ACE2
ACE2 		0.060 Biomarker disease BEFREE The AMPK-p-ACE2 S680 axis was also validated in lung tissue from humans with idiopathic pulmonary arterial hypertension. 29570986 2018
Entrez Id: 59272
Gene Symbol: ACE2
ACE2 		0.060 Biomarker disease BEFREE Moreover, magnolol inhibited angiotensin-converting enzyme (ACE)/angiotensin II (Ang II)/Ang II type 1 receptor (AT-1R) cascade, whereas upregulates ACE2 in the lungs of PAH rats. 30466619 2018
Entrez Id: 59272
Gene Symbol: ACE2
ACE2 		0.060 AlteredExpression disease BEFREE Moreover, in MVs group, ACE2 mRNA in the lung tissues and plasma levels of Ang-(1-7) were both upregulated compared with PAH group. 29752040 2018
Entrez Id: 59272
Gene Symbol: ACE2
ACE2 		0.060 Biomarker disease BEFREE However, the protective effects of ACE2 activation on PAH were counteracted by co-administration of MLN4760, an ACE2 antagonist (all P > .05). 29146157 2017