Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.010 Biomarker disease BEFREE Abnormal cholesterol metabolism may contribute to the pathogenesis of non-alcoholic steatohepatitis (NASH) and fibrosis. miR-33 and miR-144 regulate adenosine triphosphate binding cassette transporter (ABCA1) and other target genes involved in cholesterol efflux, fatty acid oxidation and inflammation. 26945479 2016
Entrez Id: 5244
Gene Symbol: ABCB4
ABCB4
0.300 Biomarker disease CTD_human Therapeutic effect of bezafibrate against biliary damage: a study of phospholipid secretion via the PPARalpha-MDR3 pathway. 20040336 2010
Entrez Id: 1244
Gene Symbol: ABCC2
ABCC2
0.300 Biomarker disease CTD_human Misregulation of membrane trafficking processes in human nonalcoholic steatohepatitis. 29341352 2018
Entrez Id: 31
Gene Symbol: ACACA
ACACA
0.010 Biomarker disease BEFREE Liver expression of key genes related to de novo FA synthesis (LXRα, SREBP1c, ACC1, FAS), FA uptake and transport (PPARγ, CD36, FABP4), FA oxidation (PPARα), and inflammation (IL6, TNFα, CRP, PPARδ) were assessed by RT-qPCR in 127 MO women with normal liver histology (NL, n = 13), simple steatosis (SS, n = 47) and non-alcoholic steatohepatitis (NASH, n = 67). 25474087 2014
Entrez Id: 38
Gene Symbol: ACAT1
ACAT1
0.020 Biomarker disease BEFREE Decades of study have utilized the <i>Mat1a</i>-knockout (KO) mouse that spontaneously develops non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) to elucidate a variety of mechanisms by which MAT proteins dysregulation contributes to liver carcinogenesis. 31496615 2019
Entrez Id: 38
Gene Symbol: ACAT1
ACAT1
0.020 AlteredExpression disease BEFREE Mice lacking the methionine adenosyltransferase (MAT) gene MAT1A exhibit a chronic reduction in hepatic S-adenosylmethionine (SAMe) levels, basal activation of LKB1, and spontaneous development of nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). 20815019 2010
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.310 AlteredExpression disease BEFREE Nonalcoholic steatohepatitis (NASH), when compared with simple steatosis (SS), significantly increases the expression of TGFB1 (6.8, p<0.005), angiotensin I-converting enzyme (ACE) (2.1, p<0.007), LAMA1 (2.1, p<0.007), SERPINB2 (2.1, p<0.007), CSF2 (2.5, p<0.002), IL1A (2.5, p<0.005), IL3 (2.1, p<0.007), IL4 (2.1, p<0.007), LIF (2.1, p<0.007), and MMP1 (2.1, p<0.007), and decreases the transcript levels of genes involved in the negative regulation of cell-death pathways. 21664615 2011
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.310 Biomarker disease CTD_human Liver transcriptional profile of atherosclerosis-related genes in human nonalcoholic fatty liver disease. 21664615 2011
Entrez Id: 48
Gene Symbol: ACO1
ACO1
0.010 AlteredExpression disease BEFREE Increased duodenal iron absorption through up-regulation of divalent metal transporter 1 from enhancement of iron regulatory protein 1 activity in patients with nonalcoholic steatohepatitis. 25753988 2015
Entrez Id: 2182
Gene Symbol: ACSL4
ACSL4
0.010 GeneticVariation disease BEFREE Pathologically, lowered methylation level (β-values <3.26) of ACSL4 (cg15536552) conferred susceptibility to nonalcoholic steatohepatitis (NASH). 29568887 2018
Entrez Id: 11093
Gene Symbol: ADAMTS13
ADAMTS13
0.030 GeneticVariation disease BEFREE We describe an unusual case of fatal recurrent TTP in a morbid obese female with non-alcoholic steatohepatitis (NASH) and severe ADAMTS13 activity deficiency due neither to an inhibitory autoantibody nor to a gene mutation. 24460705 2014
Entrez Id: 11093
Gene Symbol: ADAMTS13
ADAMTS13
0.030 Biomarker disease BEFREE Previous studies, predominantly based on increased or decreased plasma levels, have reported conflicting data on a potential functional role of ADAMTS13 in the pathogenesis of liver diseases, including non‑alcoholic steatohepatitis (NASH). 29067443 2017
Entrez Id: 11093
Gene Symbol: ADAMTS13
ADAMTS13
0.030 Biomarker disease BEFREE The aim of our study was to investigate a potential role of ADAMTS13 in formation of hepatic microthrombi and development of non-alcoholic steatohepatitis (NASH), and furthermore to evaluate whether plasmin can compensate for the absence of ADAMTS13 in removal of thrombi. 27604194 2017
Entrez Id: 11096
Gene Symbol: ADAMTS5
ADAMTS5
0.010 GeneticVariation disease BEFREE Insulin sensitivity was improved in the ADAMTS5-J KO mice, and they were protected against non-alcoholic steatohepatitis in the DIO model (as the ADAMTS5-P mice). 29293679 2018
Entrez Id: 124
Gene Symbol: ADH1A
ADH1A
0.300 Biomarker disease CTD_human Alcohol Metabolism in the Progression of Human Nonalcoholic Steatohepatitis. 29718361 2018
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.310 Biomarker disease CTD_human Alcohol Metabolism in the Progression of Human Nonalcoholic Steatohepatitis. 29718361 2018
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.310 Biomarker disease BEFREE Fourteen markers were genotyped within two alcohol metabolism genes [Alcohol dehydrogenase (ADH) gene clusters (ADH1B and ADH1C) and Aldehyde dehydrogenase (ALDH2)], one microsomal ethanol oxidizing enzyme cytochrome p450 (CYP2E1) and three oxidative stress response (OSR) genes (MnSOD, GSTT1 and GSTM1) among 490 Bengali individuals (322 ALD and 168 control) from Eastern and North-Eastern India and validation was performed in a new cohort of 150 Bengali patients including 100 ALD and 50 advanced non-alcoholic steatohepatitis (NASH). 26937962 2016
Entrez Id: 126
Gene Symbol: ADH1C
ADH1C
0.010 Biomarker disease BEFREE Fourteen markers were genotyped within two alcohol metabolism genes [Alcohol dehydrogenase (ADH) gene clusters (ADH1B and ADH1C) and Aldehyde dehydrogenase (ALDH2)], one microsomal ethanol oxidizing enzyme cytochrome p450 (CYP2E1) and three oxidative stress response (OSR) genes (MnSOD, GSTT1 and GSTM1) among 490 Bengali individuals (322 ALD and 168 control) from Eastern and North-Eastern India and validation was performed in a new cohort of 150 Bengali patients including 100 ALD and 50 advanced non-alcoholic steatohepatitis (NASH). 26937962 2016
Entrez Id: 127
Gene Symbol: ADH4
ADH4
0.300 Biomarker disease CTD_human Alcohol Metabolism in the Progression of Human Nonalcoholic Steatohepatitis. 29718361 2018
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.380 GeneticVariation disease BEFREE The people who carried the adiponectin gene promoter -11377C/G (GG)/GPx-1 gene C594T (TT) had a high risk of NAFLD (ORNAFL = 7.2800; ORNASH = 41.2941; ORNAFHC = 363.9724), and statistical analysis suggested a positive association between -11377C/G (GG) and C594T (TT) in increasing the risk of NAFLD (γ2NAFL = 2.2071, γ4 NAFL = 2.0773; γ2 NASH = 2.1084; γ4NASH = 2.0543; γ2 NAFHC = 2.1387; γ4NAFHC = 2.0004). 26897098 2016
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.380 Biomarker disease BEFREE MMP-9 activity is increased by adiponectin in primary human hepatocytes but even negatively correlates with serum adiponectin in a rodent model of non-alcoholic steatohepatitis. 21791204 2011
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.380 GeneticVariation disease BEFREE These studies 1) definitively demonstrate the presence of severe peripheral and hepatic insulin resistance in the affected subjects; 2) describe a stereotyped pattern of partial lipodystrophy associated with all the features of the metabolic syndrome and nonalcoholic steatohepatitis; 3) document abnormalities in the in vivo function of remaining adipose tissue, including the inability of subcutaneous abdominal adipose tissue to trap and store free fatty acids postprandially and the presence of very low circulating levels of adiponectin; 4) document the presence of severe hyperinsulinemia in prepubertal carriers of the proline-467-leucine (P467L) PPAR-gamma mutation; 5) provide the first direct evidence of cellular resistance to PPAR-gamma agonists in mononuclear cells derived from the patients; and 6) report on the metabolic response to thiazolidinedione therapy in two affected subjects. 12663460 2003
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.380 Biomarker disease BEFREE Angiotensin-(1-7) improves non-alcoholic steatohepatitis through an adiponectin-independent mechanism. 26992300 2017
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.380 AlteredExpression disease BEFREE Serum adiponectin level was the only predictor of nonalcoholic steatohepatitis (NASH) in this study (P=0.024). 16989692 2006
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.380 Biomarker disease CTD_human The role of adiponectin in the pathogenesis and treatment of non-alcoholic fatty liver disease. 20415685 2010