Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3077
Gene Symbol: HFE
HFE 		0.090 GeneticVariation disease BEFREE Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis. 10488699 1999
Entrez Id: 3077
Gene Symbol: HFE
HFE 		0.090 GeneticVariation disease BEFREE Nonalcoholic steatohepatitis in Asian Indians is neither associated with iron overload nor with HFE gene mutations. 15637751 2005
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		0.340 AlteredExpression disease BEFREE Nonalcoholic steatohepatitis (NASH), when compared with simple steatosis (SS), significantly increases the expression of TGFB1 (6.8, p<0.005), angiotensin I-converting enzyme (ACE) (2.1, p<0.007), LAMA1 (2.1, p<0.007), SERPINB2 (2.1, p<0.007), CSF2 (2.5, p<0.002), IL1A (2.5, p<0.005), IL3 (2.1, p<0.007), IL4 (2.1, p<0.007), LIF (2.1, p<0.007), and MMP1 (2.1, p<0.007), and decreases the transcript levels of genes involved in the negative regulation of cell-death pathways. 21664615 2011
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.310 AlteredExpression disease BEFREE Nonalcoholic steatohepatitis (NASH), when compared with simple steatosis (SS), significantly increases the expression of TGFB1 (6.8, p<0.005), angiotensin I-converting enzyme (ACE) (2.1, p<0.007), LAMA1 (2.1, p<0.007), SERPINB2 (2.1, p<0.007), CSF2 (2.5, p<0.002), IL1A (2.5, p<0.005), IL3 (2.1, p<0.007), IL4 (2.1, p<0.007), LIF (2.1, p<0.007), and MMP1 (2.1, p<0.007), and decreases the transcript levels of genes involved in the negative regulation of cell-death pathways. 21664615 2011
Entrez Id: 284217
Gene Symbol: LAMA1
LAMA1 		0.310 AlteredExpression disease BEFREE Nonalcoholic steatohepatitis (NASH), when compared with simple steatosis (SS), significantly increases the expression of TGFB1 (6.8, p<0.005), angiotensin I-converting enzyme (ACE) (2.1, p<0.007), LAMA1 (2.1, p<0.007), SERPINB2 (2.1, p<0.007), CSF2 (2.5, p<0.002), IL1A (2.5, p<0.005), IL3 (2.1, p<0.007), IL4 (2.1, p<0.007), LIF (2.1, p<0.007), and MMP1 (2.1, p<0.007), and decreases the transcript levels of genes involved in the negative regulation of cell-death pathways. 21664615 2011
Entrez Id: 5055
Gene Symbol: SERPINB2
SERPINB2 		0.310 AlteredExpression disease BEFREE Nonalcoholic steatohepatitis (NASH), when compared with simple steatosis (SS), significantly increases the expression of TGFB1 (6.8, p<0.005), angiotensin I-converting enzyme (ACE) (2.1, p<0.007), LAMA1 (2.1, p<0.007), SERPINB2 (2.1, p<0.007), CSF2 (2.5, p<0.002), IL1A (2.5, p<0.005), IL3 (2.1, p<0.007), IL4 (2.1, p<0.007), LIF (2.1, p<0.007), and MMP1 (2.1, p<0.007), and decreases the transcript levels of genes involved in the negative regulation of cell-death pathways. 21664615 2011
Entrez Id: 1437
Gene Symbol: CSF2
CSF2 		0.310 AlteredExpression disease BEFREE Nonalcoholic steatohepatitis (NASH), when compared with simple steatosis (SS), significantly increases the expression of TGFB1 (6.8, p<0.005), angiotensin I-converting enzyme (ACE) (2.1, p<0.007), LAMA1 (2.1, p<0.007), SERPINB2 (2.1, p<0.007), CSF2 (2.5, p<0.002), IL1A (2.5, p<0.005), IL3 (2.1, p<0.007), IL4 (2.1, p<0.007), LIF (2.1, p<0.007), and MMP1 (2.1, p<0.007), and decreases the transcript levels of genes involved in the negative regulation of cell-death pathways. 21664615 2011
Entrez Id: 3552
Gene Symbol: IL1A
IL1A 		0.310 AlteredExpression disease BEFREE Nonalcoholic steatohepatitis (NASH), when compared with simple steatosis (SS), significantly increases the expression of TGFB1 (6.8, p<0.005), angiotensin I-converting enzyme (ACE) (2.1, p<0.007), LAMA1 (2.1, p<0.007), SERPINB2 (2.1, p<0.007), CSF2 (2.5, p<0.002), IL1A (2.5, p<0.005), IL3 (2.1, p<0.007), IL4 (2.1, p<0.007), LIF (2.1, p<0.007), and MMP1 (2.1, p<0.007), and decreases the transcript levels of genes involved in the negative regulation of cell-death pathways. 21664615 2011
Entrez Id: 3976
Gene Symbol: LIF
LIF 		0.310 AlteredExpression disease BEFREE Nonalcoholic steatohepatitis (NASH), when compared with simple steatosis (SS), significantly increases the expression of TGFB1 (6.8, p<0.005), angiotensin I-converting enzyme (ACE) (2.1, p<0.007), LAMA1 (2.1, p<0.007), SERPINB2 (2.1, p<0.007), CSF2 (2.5, p<0.002), IL1A (2.5, p<0.005), IL3 (2.1, p<0.007), IL4 (2.1, p<0.007), LIF (2.1, p<0.007), and MMP1 (2.1, p<0.007), and decreases the transcript levels of genes involved in the negative regulation of cell-death pathways. 21664615 2011
Entrez Id: 4312
Gene Symbol: MMP1
MMP1 		0.310 AlteredExpression disease BEFREE Nonalcoholic steatohepatitis (NASH), when compared with simple steatosis (SS), significantly increases the expression of TGFB1 (6.8, p<0.005), angiotensin I-converting enzyme (ACE) (2.1, p<0.007), LAMA1 (2.1, p<0.007), SERPINB2 (2.1, p<0.007), CSF2 (2.5, p<0.002), IL1A (2.5, p<0.005), IL3 (2.1, p<0.007), IL4 (2.1, p<0.007), LIF (2.1, p<0.007), and MMP1 (2.1, p<0.007), and decreases the transcript levels of genes involved in the negative regulation of cell-death pathways. 21664615 2011
Entrez Id: 3565
Gene Symbol: IL4
IL4 		0.310 AlteredExpression disease BEFREE Nonalcoholic steatohepatitis (NASH), when compared with simple steatosis (SS), significantly increases the expression of TGFB1 (6.8, p<0.005), angiotensin I-converting enzyme (ACE) (2.1, p<0.007), LAMA1 (2.1, p<0.007), SERPINB2 (2.1, p<0.007), CSF2 (2.5, p<0.002), IL1A (2.5, p<0.005), IL3 (2.1, p<0.007), IL4 (2.1, p<0.007), LIF (2.1, p<0.007), and MMP1 (2.1, p<0.007), and decreases the transcript levels of genes involved in the negative regulation of cell-death pathways. 21664615 2011
Entrez Id: 3562
Gene Symbol: IL3
IL3 		0.310 AlteredExpression disease BEFREE Nonalcoholic steatohepatitis (NASH), when compared with simple steatosis (SS), significantly increases the expression of TGFB1 (6.8, p<0.005), angiotensin I-converting enzyme (ACE) (2.1, p<0.007), LAMA1 (2.1, p<0.007), SERPINB2 (2.1, p<0.007), CSF2 (2.5, p<0.002), IL1A (2.5, p<0.005), IL3 (2.1, p<0.007), IL4 (2.1, p<0.007), LIF (2.1, p<0.007), and MMP1 (2.1, p<0.007), and decreases the transcript levels of genes involved in the negative regulation of cell-death pathways. 21664615 2011
Entrez Id: 338
Gene Symbol: APOB
APOB 		0.020 GeneticVariation disease BEFREE Non-alcoholic steatohepatitis-related cirrhosis in a patient with APOB L343V familial hypobetalipoproteinaemia. 23694813 2013
Entrez Id: 6579
Gene Symbol: SLCO1A2
SLCO1A2 		0.010 AlteredExpression disease BEFREE Non-alcoholic steatohepatitis (NASH) in humans and in a diet-induced rodent model alter the expression of multiple OATP transporters. 24613363 2014
Entrez Id: 367
Gene Symbol: AR
AR 		0.020 Biomarker disease BEFREE Nonalcoholic steatohepatitis-related hepatocellular carcinoma: is there a role for the androgen receptor pathway? 28424556 2017
Entrez Id: 8837
Gene Symbol: CFLAR
CFLAR 		0.030 Biomarker disease BEFREE Non-alcoholic steatohepatitis (NASH) is a chronic metabolic syndrome and the CFLAR-JNK pathway can reverse the process of NASH. 31384535 2019
Entrez Id: 5599
Gene Symbol: MAPK8
MAPK8 		0.040 Biomarker disease BEFREE Non-alcoholic steatohepatitis (NASH) is a chronic metabolic syndrome and the CFLAR-JNK pathway can reverse the process of NASH. 31384535 2019
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ 		0.380 Biomarker disease BEFREE Adiponectin and its receptors in non-alcoholic steatohepatitis. 15591515 2005
Entrez Id: 5465
Gene Symbol: PPARA
PPARA 		0.390 GeneticVariation disease BEFREE Peroxisome proliferator-activated receptor alpha L162V polymorphism in nonalcoholic steatohepatitis and genotype 1 hepatitis C virus-related liver steatosis. 16297361 2005
Entrez Id: 1118
Gene Symbol: CHIT1
CHIT1 		0.010 AlteredExpression disease BEFREE CHIT expression differed markedly in livers from normal controls and in those from patients with simple steatosis or non-alcoholic steatohepatitis. 16825325 2006
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.100 Biomarker disease BEFREE Tumor necrosis factor (TNF) is considered to play a role in the second hit of non-alcoholic steatohepatitis (NASH). 17395331 2007
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR 		0.010 GeneticVariation disease BEFREE Methylenetetrahydrofolate reductase gene polymorphisms in patients with nonalcoholic steatohepatitis (NASH). 17563923 2008
Entrez Id: 3077
Gene Symbol: HFE
HFE 		0.090 GeneticVariation disease BEFREE HFE C282Y mutations are associated with advanced hepatic fibrosis in Caucasians with nonalcoholic steatohepatitis. 17680648 2007
Entrez Id: 3929
Gene Symbol: LBP
LBP 		0.020 AlteredExpression disease BEFREE Lipopolysaccharide-binding protein plasma levels and liver TNF-alpha gene expression in obese patients: evidence for the potential role of endotoxin in the pathogenesis of non-alcoholic steatohepatitis. 18000721 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.310 Biomarker disease BEFREE PTEN in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and cancer. 20460918 2010