Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | AlteredExpression | disease | BEFREE | The granulocyte-specific microRNA-223 (miR-223) has recently emerged as a negative regulator of NOD-like receptor 3 (NLRP3) expression, a central key player in chronic hepatic injuries such as fibrotic nonalcoholic steatohepatitis (NASH), as well as in other liver conditions including acute hepatitis. | 31585800 | 2020 | ||||
|
0.070 | Biomarker | disease | BEFREE | Impaired mitophagy triggers NLRP3 inflammasome activation during the progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis. | 30700851 | 2019 | ||||
|
0.070 | Biomarker | disease | BEFREE | In this study, we test the hypothesis that TXNIP-NLRP3 axis repression prevents against intestinal barrier function disruption in nonalcoholic steatohepatitis (NASH). | 30387131 | 2019 | ||||
|
0.070 | Biomarker | disease | BEFREE | Microvesicles released from fat-laden cells promote activation of hepatocellular NLRP3 inflammasome: A pro-inflammatory link between lipotoxicity and non-alcoholic steatohepatitis. | 28249038 | 2017 | ||||
|
0.070 | Biomarker | disease | BEFREE | From the various inflammasomes, the NLRP3 inflammasome has been increasingly implicated in the pathogenesis of chronic inflammatory liver diseases, including nonalcoholic steatohepatitis, a disease process that is soaring and has evolved as a primary cause of liver fibrosis and need for liver transplantation. | 28564720 | 2017 | ||||
|
0.070 | Biomarker | disease | BEFREE | However, the role of NLRP3 played in the non-alcoholic steatohepatitis (NASH) has yet to be evaluated. | 28730512 | 2017 | ||||
|
0.070 | Biomarker | disease | BEFREE | NOD-like receptor (NLR) NLRP3 inflammasome activation has been implicated in the progression of non-alcoholic fatty liver disease (NAFLD) from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH). | 28499273 | 2017 |