Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.340 AlteredExpression disease BEFREE These data demonstrated novel molecular events for leptin inhibition of PPARγ1 expression in HSCs and thus might have potential implications for clarifying the detailed mechanisms underlying liver fibrosis in diseases in which circulating leptin levels are elevated such as non-alcoholic steatohepatitis in obese patients. 27709831 2017
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.340 Biomarker disease BEFREE This study was designed to evaluate the pro-inflammatory and pro-oxidant effects of leptin and linoleic acid on immune cells from patients with NAFLD and to corroborate the modulatory effects of curcumin and its preventive properties against the progression of NAFLD using a high-fat diet (HFD)-induced NAFLD/nonalcoholic steatohepatitis mouse model. 28257515 2017
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.340 Biomarker disease CTD_human CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis. 24211274 2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.340 Biomarker disease BEFREE Furthermore, BAIBA could have favourable effects on nonalcoholic steatohepatitis in a leptin-independent manner. 19735301 2010
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.340 Biomarker disease BEFREE The main aim of this study was to examine the relationship of the leptin system in steatosis and nonalcoholic steatohepatitis (NASH). 17032406 2006