Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.030 AlteredExpression disease BEFREE Skeletal muscle miR-34a/SIRT1:AMPK axis is activated in experimental and human non-alcoholic steatohepatitis. 31139863 2019
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.030 Biomarker disease BEFREE Disease-specific miR-34a as diagnostic marker of non-alcoholic steatohepatitis in a Chinese population. 27956809 2016
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.030 Biomarker disease BEFREE Here we show that hepatocyte nuclear factor 4α (HNF4α), a liver-enriched nuclear hormone receptor, is markedly inhibited, whereas miR-34a is highly induced in patients with non-alcoholic steatohepatitis, diabetic mice and mice fed a high-fat diet. miR-34a is essential for HNF4α expression and regulates triglyceride accumulation in human and murine hepatocytes. miR-34a inhibits very low-density lipoprotein secretion and promotes liver steatosis and hypolipidemia in an HNF4α-dependent manner. 26100857 2015