Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE In patients with nonalcoholic steatohepatitis (NASH), PNPLA3 GG compared to CC was associated with higher AST levels [38.4±25.3 versus 36.7±40.1IU/L, p=0.0395)] and with the presence of liver fibrosis (≥F2 fibrosis, p=0.0272). 31054980 2020
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE The progression of NAFLD, including nonalcoholic steatohepatitis (NASH), has a strong genetic component, and the most robust contributor is the patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 encoding the 148M protein sequence variant. 30772256 2019
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease GWASCAT Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers. 29385134 2018
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE The patatin-like phospholipase domain-containing 3 (PNPLA3) gene has been associated with the development of alcoholic and nonalcoholic steatohepatitis. 30218427 2018
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 Biomarker disease BEFREE The Combination of Blueberry Juice and Probiotics Ameliorate Non-Alcoholic Steatohepatitis (NASH) by Affecting SREBP-1c/PNPLA-3 Pathway via PPAR-α. 28264426 2017
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE A single nucleotide polymorphism (SNP) in the patatin-like phospholipase domain containing 3 gene (PNPLA3, rs738409) has been associated with fibrosis and development of hepatocellular carcinoma (HCC) in patients with nonalcoholic steatohepatitis, although its association with outcomes in patients with hepatitis C virus (HCV) infection is less clear. 26305067 2016
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 AlteredExpression disease BEFREE We used real-time polymerase chain reaction (PCR) analysis to analyze the hepatic expression of PNPLA3 and lipid metabolism-related genes in 55 morbidly obese subjects with normal liver histology (NL, n = 18), simple steatosis (SS, n = 20), and non-alcoholic steatohepatitis (NASH, n = 17). 27128907 2016
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE PNPLA3 genotype increases susceptibility of nonalcoholic steatohepatitis among obese patients with nonalcoholic fatty liver disease. 25240529 2016
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 Biomarker disease CTD_human Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way. 27180240 2016
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE Interactions of a PPARGC1A Variant and a PNPLA3 Variant Affect Nonalcoholic Steatohepatitis in Severely Obese Taiwanese Patients. 27015186 2016
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE A single nucleotide polymorphism (SNP) of the PNPLA3-gene is associated with development of non-alcoholic steatohepatitis and a worse outcome in alcoholic liver disease. 26599080 2015
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE In patients with both CHB and NAFLD, these genotypes of PNPLA3 polymorphisms were associated with increased susceptibility to nonalcoholic steatohepatitis (NASH) (NAFLD activity score ≥ 3; P = 0.01-0.03) and liver fibrosis (> 1 Metavir grading; P = 0.01-0.04). 26229402 2015
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 Biomarker disease BEFREE The patatin-like phospholipase domain-containing 3 gene (PNPLA3) has been associated with liver steatosis and disease progression in nonalcoholic steatohepatitis and chronic hepatitis C. 25986529 2015
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE We conducted a meta-analysis to assess the association between patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 polymorphism and nonalcoholic fatty liver disease (NAFLD) and its subtypes simple steatosis(SS) and nonalcoholic steatohepatitis (NASH). 25791171 2015
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 Biomarker disease BEFREE PNPLA3 is associated with an increased risk of advanced fibrosis among patients with a variety of liver diseases and is an independent risk factor for HCC among patients with nonalcoholic steatohepatitis or alcohol-related cirrhosis. 24445574 2014
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 Biomarker disease CTD_human Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease. 24531328 2014
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE Genetic variants in the PNPLA3 gene are associated with nonalcoholic steatohepatitis. 24831885 2014
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE The percentage of patients with non-alcoholic steatohepatitis (NASH) was significantly different according to the PNPLA3 variant. 23512881 2013
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE Recently, the common variant p.I148M of the enzyme adiponutrin (PNPLA3) has emerged as a major genetic determinant of hepatic steatosis and nonalcoholic steatohepatitis as well as its pathobiological sequelae fibrosis, cirrhosis, and hepatocellular cancer. 24222094 2013
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE In this study, we investigated the interactions of PNPLA3 rs738409 with a broad panel of metabolic and histologic characteristics of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (NASH) in patients with medically complicated obesity. 23418085 2013
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 GeneticVariation disease BEFREE In patients with NAFLD, adiponutrin rs738409 C-->G genotype, encoding for rs738409" genes_norm="80339">I148M, is associated with the severity of steatosis and fibrosis and the presence of nonalcoholic steatohepatitis. 20373368 2010
Entrez Id: 80339
Gene Symbol: PNPLA3
PNPLA3
0.500 Biomarker disease CTD_human Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. 18820647 2008
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker disease BEFREE Carbon monoxide releasing molecule-A1 improves nonalcoholic steatohepatitis via Nrf2 activation mediated improvement in oxidative stress and mitochondrial function. 31514051 2020
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker disease BEFREE Adropin protects against liver injury in nonalcoholic steatohepatitis via the Nrf2 mediated antioxidant capacity. 30684890 2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker disease BEFREE Nrf2-mediated anti-oxidant effects contribute to suppression of non-alcoholic steatohepatitis-associated hepatocellular carcinoma in murine model. 30279623 2018