Multi-parametric MRI (MP-MRI) prior to prostate biopsy is the investigation of choice for an elevated age-related PSA and abnormal digital rectal examination.
Even with a signal acquisition frequency of 55 droplets per minute, the multi-FRET biosensing system has linear ranges of 0.50-70 ng mL<sup>-1</sup> for CEA, 0.25-70 ng mL<sup>-1</sup> for PSA and 0.50-70 ng mL<sup>-1</sup> for VEGF<sub>165</sub>.
Recent studies suggested that PSA-density (PSA-D) in combination with multi-parametric prostate MR as well as bp-MR may achieve a higher diagnostic accuracy than either alone.
<b>Purpose:</b> To investigate whether prebiopsy multi-parametric (mp) MRI can help to improve predictive performance in prostate cancer.<b>Experimental Design:</b> Based on a support vector machine (SVM) analysis, we prospectively modeled clinical data (age, PSA, digital rectal examination, transrectal ultrasound, PSA density, and prostate volume) and mp-MRI findings [Prostate Imaging and Reporting and Data System (PI-RADS) score and tumor-node-metastasis stage] in 985 men to predict the risk of prostate cancer.