Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4437
Gene Symbol: MSH3
MSH3
0.100 Biomarker disease BEFREE We provide the first evidence that enhanced cytosolic sensing of Ld-DNA in infection by antimony resistant (SBR-LD), but not antimony sensitive L.donovani strains (SBS-LD), was critically regulated by host MDRs, multi drug resistant associated protein 1 (MRP 1) and permeability glycoprotein (P-gp) in macrophages. 31285443 2019
Entrez Id: 4437
Gene Symbol: MSH3
MSH3
0.100 Biomarker disease BEFREE In the present study, it was found that Ori significantly suppressed DDP-resistant human SGC7901/DDP cell proliferation, growth and colony formation, causing increased caspase-dependent apoptosis, decreased expression of P-glycoprotein (P-gp), encoded by the MDR gene, multi-drug resistance-associated protein (MRP1), and cyclin D1. 28781688 2017
Entrez Id: 4437
Gene Symbol: MSH3
MSH3
0.100 AlteredExpression disease BEFREE Silencing of microRNA-127 also significantly reduced the mRNA and protein expression levels of MDR1 and MRP1, which are major ATP-binding cassette (ABC) transporter linked to multi-drug resistance in cancer cells. 26261488 2015
Entrez Id: 4437
Gene Symbol: MSH3
MSH3
0.100 Biomarker disease BEFREE PEITC inhibited cisplatin-resistant human SGC7901/DDP cell growth in a dose-dependent manner, causing increased apoptosis, ROS generation, glutathione depletion, accumulation of Rhodamine-123, decreased expression of P-glycoprotein and cell cycle arrest. mRNA and protein expression of the multi-drug resistance gene (MDR1), multi-drug resistance-associated protein (MRP1), excision repair cross-complementing gene 1 (ERCC1), survivin, and Mad2 was decreased, and phosphorylation of Akt and transcriptional activation of NF-κB were suppressed. 23956061 2014
Entrez Id: 4437
Gene Symbol: MSH3
MSH3
0.100 Biomarker disease BEFREE We found that vinorelbine increased drug sensitivity to cisplatin and intracellular accumulation of rhodamine-123, while decreasing expression of P-glycoprotein (P-gp), multi-drug resistance-associated protein (MRP1) and glutathione-S-transferase Π (GST-Π) in A549/DDP cells. 24083716 2013
Entrez Id: 4437
Gene Symbol: MSH3
MSH3
0.100 AlteredExpression disease BEFREE PCR data showed that MRP1 was more highly expressed when compared to another ATP-binding cassette family, multi-drug resistant protein and the expression levels of MRP1 on the cells were specifically dose- and time-dependently depleted by the addition of SAL. 22083453 2012
Entrez Id: 4437
Gene Symbol: MSH3
MSH3
0.100 Biomarker disease BEFREE Detection and characterisation of multi-drug resistance protein 1 (MRP-1) in human mitochondria. 22353810 2012
Entrez Id: 4437
Gene Symbol: MSH3
MSH3
0.100 Biomarker disease BEFREE The three major candidates accounting for the development of MDR in acute myeloid leukaemia (AML) are multi drug resistance gene (MDR1), multi drug resistance-related protein gene (MRP1) and lung resistance protein gene (LRP). 15667534 2005
Entrez Id: 4437
Gene Symbol: MSH3
MSH3
0.100 Biomarker disease BEFREE In addition, we measured the mRNA expression of multi drug resistance protein 1 (MDR-1), multi drug resistance related protein 1 (MRP-1) and breast cancer resistance protein (BCRP) by real-time PCR analysis after treatment with AN-215. 16322338 2005
Entrez Id: 4437
Gene Symbol: MSH3
MSH3
0.100 Biomarker disease BEFREE Fresh frozen samples of 45 primary OSCC were investigated for the expression of mdr1 (p-glycoprotein-mediated multi-drug resistance), mrp1 (multi-drug resistance-related protein) and bcrp (breast cancer-related protein), using a reverse transcriptase PCR. 15113040 2004