Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.900 | Biomarker | disease | MGD | VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease. | 26203154 | 2015 | ||||
|
0.900 | GeneticVariation | disease | UNIPROT | Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy. | 24819384 | 2014 | ||||
|
0.900 | Biomarker | disease | GENOMICS_ENGLAND | Frequency of the ASP620ASN mutation in VPS35 and Arg1205His mutation in EIF4G1 in familial Parkinson's disease from South Italy. | 24854799 | 2014 | ||||
|
0.900 | GeneticVariation | disease | UNIPROT | Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation. | 24980502 | 2014 | ||||
|
0.900 | GeneticVariation | disease | UNIPROT | RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk. | 23395371 | 2013 | ||||
|
0.900 | Biomarker | disease | GENOMICS_ENGLAND | Whole exome sequencing of rare variants in EIF4G1 and VPS35 in Parkinson disease. | 23408866 | 2013 | ||||
|
0.900 | GeneticVariation | disease | UNIPROT | Identification of VPS35 mutations replicated in French families with Parkinson disease. | 22517097 | 2012 | ||||
|
0.900 | GeneticVariation | disease | UNIPROT | VPS35 mutations in Parkinson disease. | 21763482 | 2011 | ||||
|
0.900 | GeneticVariation | disease | UNIPROT | A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease. | 21763483 | 2011 | ||||
|
0.900 | Biomarker | disease | GENOMICS_ENGLAND | |||||||
|
0.900 | Biomarker | disease | CTD_human | |||||||
|
0.900 | CausalMutation | disease | CLINVAR |