Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 GeneticVariation group BEFREE We analyzed p16INK4A and p15INK4B genes in 178 cases of primary leukemias including 81 cases of chronic lymphocytic leukemia (CLL), seven of hairy cell leukemia (HCL), seven of chronic myelogenous leukemia (CML), 43 of acute myelogenous leukemia (AML), 27 of acute lymphoblastic leukemia (ALL), and 13 of myelodysplastic syndrome (MDS) by Southern blot analyses. 7795238 1995
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 PosttranslationalModification group BEFREE These results suggest that hypermethylation of the p15INK4B gene is involved in the pathogenesis of MDS and is one of the important late events during the development of MDS. 9269757 1997
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 PosttranslationalModification group BEFREE Our results showed that methylation of the p15(INK4b) gene in MDS is correlated with blastic bone marrow involvement and increases with disease evolution toward AML. 9531610 1998
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 PosttranslationalModification group BEFREE Since several TSGs and growth regulatory genes, including the p15INK4B gene, may be inactivated through promoter hypermethylation in hematological malignancies, modulation of the methylation status may be considered as a novel treatment modality in MDS. 10036997 1998
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 PosttranslationalModification group BEFREE It was recently shown that the promoter of the p15INK4b but not the p16INK4a gene is frequently and selectively hypermethylated in MDS. 10609781 1999
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 PosttranslationalModification group BEFREE Because DNA modified by sodium bisulfite is also available for assessment of methylation status of other genes by setting specific primers for them, we performed the simultaneous assessment of clonality and aberrant hypermethylation of p15INK4B gene in myelodysplastic syndromes. 10637497 2000
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 PosttranslationalModification group BEFREE In this study, we analyzed the methylation status of the p15INK4B gene in MDS by the methylation-specific PCR (MSP) method, which is more sensitive than Southern blotting. 10764143 2000
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 PosttranslationalModification group BEFREE In conclusion, p15(INK4B) methylation can be detected early at the diagnosis of MDS or acquired during disease progression. 11167795 2001
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 PosttranslationalModification group BEFREE This TGF-beta1-dependent pathway is altered in MDS CD34(+) progenitors because of p15 methylation. 11435325 2001
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 PosttranslationalModification group BEFREE Hypermethylation of the p15(INK4B) gene occurs frequently in leukemia and high-risk MDS. 12150726 2002
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 AlteredExpression group BEFREE The emergence of partially demethylated epigenotypes and re-establishment of normal p15 protein expression following the initial decitabine courses implicate pharmacologic demethylation as a possible mechanism resulting in hematologic response in MDS. 12351408 2002
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 Biomarker group BEFREE The important cell cycle regulatory gene p15(INK4b) has been shown to be inactivated in acute myeloid leukemia and myelodysplastic syndrome. 12750705 2003
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 Biomarker group BEFREE Nevertheless, some genes like p15INK4B in myelodysplastic syndrome (MDS) and p16INK4A in some lung cancer subtypes have been shown to confer a certain prognosis. 12930158 2003
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 PosttranslationalModification group BEFREE Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia. 12970781 2003
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 Biomarker group BEFREE Progression of diseases such as MDS to secondary AML occur as a result of changes in the balance between cell proliferation and apoptosis and we will review targets in both these areas, including reversal of epigenetic silencing of genes such as p15(INK4B). 14757535 2004
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 PosttranslationalModification group BEFREE The frequency of p15 hypermethylation in paediatric MDS was 78% (7/9), which was comparable to that in adult MDS. 15755284 2005
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 Biomarker group BEFREE Although FHIT and p15(INK4B) methylations were not correlated in MDS and AML, increased FHIT methylation at the relapse in AML was associated with p15(INK4B) methylation. 15902282 2005
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 PosttranslationalModification group BEFREE Hypermethylation of p15(INK4b) in MDS is reversed during treatment with decitabine, resulting in reactivation of this gene. 16292549 2005
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 PosttranslationalModification group BEFREE Concurrent hypermethylation of > or = 3 genes was more frequent in advanced compared with early-stage MDS (P < or = 0.05), and hypermethylation of p15INK4B was associated with leukemic transformation in early MDS (P < or = 0.05). 16343268 2006
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 Biomarker group BEFREE Since the function of cell cycle control genes including the cyclin-dependent kinase inhibitors known as p15(INK4b) and p16(INK4a), as well as p14(ARF) which blocks MDM-2 (an inhibitor of p53), the retinoblastoma (RB1) protein and the mismatch repair gene MGMT is critical for hematopoietic proliferation and differentiation, we performed methylation specific polymerase chain reaction (MSP) in low-density, non-adherent bone marrow cells from 49 patients with MDS. 16682076 2006
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 PosttranslationalModification group BEFREE Our findings indicate that CALCA and CDKN2B are frequently methylated in pediatric MDS. 16890288 2007
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 GeneticVariation group LHGDN Our findings indicate that CALCA and CDKN2B are frequently methylated in pediatric MDS. 16890288 2007
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 PosttranslationalModification group BEFREE Extensive statistical analyses of the whole CpG island revealed for the first time disease-specific methylation patterns of the CDKN2B gene in myeloid malignancies and small regions of differential methylation with high discriminatory power that enabled differentiation of even low-grade myelodysplastic syndrome samples from the controls, a result that was confirmed in an independent group of 9 control and 36 patient samples. 17095538 2007
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 Biomarker group CTD_human P15INK4B gene hypermethylation is closely associated with MDS pathogenesis. 17294728 2007
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B
0.400 PosttranslationalModification group BEFREE In this study, we examined the P15(INK4B) gene promoter methylation in patients with myelodysplastic syndrome and acute leukemia and its possible relationship with parvovirus B19 and Epstein-Barr virus infections. 18384396 2009