| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | GeneticVariation | group | BEFREE | We concluded that GSTM1 deletion may contribute toward MDS progression probably due to toxic metabolite accumulation which generates cell toxicity and DNA damage. | 23684483 | 2013 | ||||
|
0.090 | GeneticVariation | group | BEFREE | GSTT1 and GSTM1 polymorphisms and myelodysplastic syndrome risk: a systematic review and meta-analysis. | 19816935 | 2010 | ||||
|
0.090 | GeneticVariation | group | BEFREE | It has been hypothesised that individuals with homozygous deletion of the GSTM1 and/or GSTT1 gene may have lower detoxification capacity towards genotoxic agents therefore those individuals may be at increased risk of myelodysplastic syndrome which is a preleukemic condition. | 18493876 | 2008 | ||||
|
0.090 | Biomarker | group | LHGDN | There seems to be an increased risk for AA and MDS in individuals lacking GSTT1 or both GSTM1/GSTT1. | 14752874 | 2004 | ||||
|
0.090 | GeneticVariation | group | BEFREE | Our purpose was to examine whether the GSTM1 and GSTT1 homozygous null genotypes have an impact on the response to recombinant human erythropoietin (rhuEpo) treatment in MDS patients. | 15595630 | 2004 | ||||
|
0.090 | GeneticVariation | group | BEFREE | In this study, we tested whether null genotypes for the GSTM1 and GSTT1 genes altered the risks for MDS, AML and AA. | 11488937 | 2001 | ||||
|
0.090 | GeneticVariation | group | BEFREE | Screening for the deletion of the GSTM1 and GSTT1 genes may be useful for assessing individual genetic susceptibility to smoking-related lung cancer and MDS. | 10616169 | 1999 | ||||
|
0.090 | GeneticVariation | group | BEFREE | In addition, analysis of polymorphisms at two loci [glutathione S-transferase T1 and M1 (GSTT1 and GSTM1)] involved in carcinogen detoxification and associated with cancer susceptibility, including increased risk for MDS, showed no evidence for enhanced sensitivity to environmental carcinogens in affected family members. | 9723026 | 1998 | ||||
|
0.090 | GeneticVariation | group | BEFREE | The GSTM1 null genotype was not associated with increased risk of MDS (odds ratio 0.8, 0.5-1.3). | 8569364 | 1996 |