Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 867
Gene Symbol: CBL
CBL
0.400 Biomarker group BEFREE UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO. 26449661 2016
Entrez Id: 867
Gene Symbol: CBL
CBL
0.400 Biomarker group BEFREE Genes significantly differentially expressed at the transcript and/or exon level in SF3B1 mutant compared with wild-type cases include genes that are involved in MDS pathogenesis (ASXL1 and CBL), iron homeostasis and mitochondrial metabolism (ALAS2, ABCB7 and SLC25A37) and RNA splicing/processing (PRPF8 and HNRNPD). 25428262 2015
Entrez Id: 867
Gene Symbol: CBL
CBL
0.400 GeneticVariation group BEFREE Recent studies are shedding light on the molecular basis of myelodysplasia and how mutations and epimutations can induce and promote this neoplastic process through aberrant transcription factor function (RUNX1, ETV6, TP53), kinase signalling (FLT3, NRAS, KIT, CBL) and epigenetic deregulation (TET2, IDH1/2, DNMT3A, EZH2, ASXL1, SF3B1, U2AF1, SRSF2, ZRSR2). 24903747 2014
Entrez Id: 867
Gene Symbol: CBL
CBL
0.400 GeneticVariation group BEFREE Because detailed clinical and hematological characteristics of CBL-mutated cases is lacking, we screened 156 BCR-ABL and JAK2 V617F negative patients with myeloproliferative neoplasms (MPN) and overlap syndromes between myelodysplastic syndrome (MDS) and MPN (MPS/MPN) for mutations in exons 8 and 9 of CBL by denaturing high-performance liquid chromatography and direct sequencing. 23010802 2012
Entrez Id: 867
Gene Symbol: CBL
CBL
0.400 GeneticVariation group BEFREE The presence of CBL mutations and 11q-aUPD was an important "second hit" that could be an indicator of leukemic transformation of MDS or AML in patients with FPD/AML. 22138511 2012
Entrez Id: 867
Gene Symbol: CBL
CBL
0.400 Biomarker group BEFREE Accordingly, in addition to classical oncogenic abnormalities, such as p53 abnormalities, or NRAS mutation, various molecular abnormalities, such as TET2, RPS14, or c-CBL, have been identified and/or proposed as the novel candidates for molecular basis of the development and progression of MDS. 21902648 2011
Entrez Id: 867
Gene Symbol: CBL
CBL
0.400 GeneticVariation group BEFREE The findings suggest that C-CBL mutations play a role at least in part in a subset of MDS patients during sAML transformation. 22131879 2011
Entrez Id: 867
Gene Symbol: CBL
CBL
0.400 GeneticVariation group BEFREE CBL missense mutations have recently been associated with juvenile myelomonocytic leukaemia (JMML), an aggressive myeloproliferative and myelodysplastic neoplasm of early childhood characterised by excessive macrophage/monocyte proliferation. 20543203 2010
Entrez Id: 867
Gene Symbol: CBL
CBL
0.400 GeneticVariation group BEFREE Clonal selection of 11q CN-LOH and CBL gene mutation in a serially studied patient during MDS progression to AML. 20674974 2010
Entrez Id: 867
Gene Symbol: CBL
CBL
0.400 Biomarker group BEFREE The cDNA of 300 acute myeloid leukemia (AML)/myelodysplastic syndrome (MDS) and acute lymphoblastic leukemia (ALL) patients and 82 human leukemic cell lines was screened for aberrations in the linker and RING finger domain of CBL. 19276253 2009
Entrez Id: 867
Gene Symbol: CBL
CBL
0.400 CausalMutation group CGI