|
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Conducted in Iran, this study was originally intended to investigate every possible association between HLA DRB1 alleles and a susceptibility to JIA.
|
29942445 |
2018 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
In summary, our meta-analysis showed four main findings regarding HLA-DRB1 locus as a genetic factor of JIA: i) HLA-DRB1*08 is a strong factor predisposing to JIA, both for oligo-articular and poly-articular forms (oJIA>pJIA); ii) HLA-DRB1*01 and HLA-DRB1*04 may be involved in the genetic predisposition of Rheumatoid Factor (RF) positive forms of JIA; iii) HLA-DRB1*11 was confirmed to be predisposing to oligo-articular JIA; iv) HLA-DRB1*04 was confirmed to have a role in systemic JIA.
|
29037901 |
2017 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
PADI4 and the HLA-DRB1 shared epitope in juvenile idiopathic arthritis.
|
28182665 |
2017 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
High-resolution HLA-DRB1 genotyping was performed in 107 children with oligoarticular and polyarticular rheumatoid factor (RF) negative JIA and 373 non-Hispanic white controls.
|
26393471 |
2015 |
|
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
RF-positive polyarticular JIA is associated with many of the shared epitope encoding HLA DRB1 alleles, as well as PTPN22, STAT4 and TNFAIP3 variants.ERA is associated with HLA B27.
|
26305060 |
2015 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
We also found an association between HLA-DRB1(*)04:05 and polyarticular JIA.
|
21179106 |
2011 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*11 was found to be the most frequent allele associated with oligoarthritis and RF negative polyarthritis JIA in Iran followed by HLA-DRB1*8.
|
21820608 |
2011 |
|
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The profile of HLA-DRB1 alleles associations in Mexican with JIA were somewhat distinct from association typically found in Caucasians.
|
20346252 |
2010 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
DRB1*1501 was shown to reduce risk across the whole cohort, whereas DRB1*0401 and DRB1*0701 were protective for selected JIA subtypes.
|
20191588 |
2010 |
|
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our results confirm that certain HLA-DRB1 alleles reported previously as susceptibility factors are strongly associated with JIA in a Hungarian population.
|
19210888 |
2009 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
A further set of 228 UK Caucasian patients with long-standing JIA were fully genotyped for HLA-DRB1 using PCR with sequence-specific primers.
|
16495319 |
2006 |
|
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Stratification of the haplotype data suggested that susceptibility to JIA in the haplotype spanning the SLC11A1 locus is independent (P < 0.01) of an association with a DRB1 JIA shared epitope (DRB1*JIASE) that includes well-characterized strong susceptibility to DRB1*08 and *11 alleles.
|
15641099 |
2005 |
|
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We found DRB1*0801/DQB1*0402 haplotype to be strongly associated (p < 0.001) with JIA, supporting findings of the haplotype associations-based ASP design.
|
15517645 |
2004 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos.
|
15120191 |
2004 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
The frequency of HLA-DRB1*1502 was higher in Taiwanese JIA patients with systemic arthritis than in controls (OR 18.09, 95% CI 2.25-145.73).
|
15265024 |
2004 |
|
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
HLA-DRB1, TAP2/TAP1, and HLA-DPB1 haplotypes in Finnish juvenile idiopathic arthritis: more complexity within the MHC.
|
15343265 |
2004 |
|
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
In the present study, we investigated whether alleles at D6S265, or other markers in this region, also modify the risk for JIA on other haplotypes, i.e., DRB1*1301-DQB1*0603 or DRB1*1101/4-DQB1*0301.
|
12622778 |
2003 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Role of human leukocyte antigen DRB1*0307 and DRB1*0308 in susceptibility to juvenile rheumatoid arthritis.
|
12846065 |
2003 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
These findings are consistent with the most compelling results of previous reports on HLA associations and suggest a JIA DRB1 shared epitope encompassing critical amino-acid residues in the third hypervariable region of this molecule.
|
12847547 |
2003 |
|
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Also, a non-significant increase in the frequency of the DRB1*04, *11 and *15 alleles was detected in the polyarticular subtype of the Kuwaiti JRA cases compared to the controls.
|
11841481 |
2002 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
No haplotypes which carried DQA1*0401 and DQB1*0402 in the absence of DRB1*08 were found, either among patients with JIA (Polish and Norwegian) or among the controls (Polish).
|
11874841 |
2002 |
|
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
JIA is associated with particular alleles at, at least, three different HLA loci: HLA-A (HLA-A*0201), -DR/DQ (DRB1*08, DRB1*11, DRB1*13) and -DP (DPB1*0201, DPB1*0301), with marked differences between the disease subtypes.
|
12195624 |
2002 |
|
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Three haplotypes (DRB1*08-DQA1*0401-DQB1*0402; DRB1*11-DQA1*05-DQB1*03; DRB1*1301-DQA1*01-DQB1*06) were associated with increased risk and one (DRB1*04-DQA1*03-DQB1*03) with decreased risk of JIA.
|
12364641 |
2002 |
|
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A common HLA-DRB1* allele was not involved in the JCA groups and subgroups studied; on the other hand, the DQA1*0501 allele was found to be associated with different JCA groups/subgroups (O-JCA, P-JCA RF-negative ANA-positive, JCA with CAU), probably suggesting a closer relationship of this locus with the immunogenetic background of JCA.
|
10457895 |
1999 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Stratification of the EOPA-JCA group into antinuclear antibody (ANA) positive (n = 18) and ANA negative (n = 25) individuals revealed that ANA positivity was only associated with DRB1*1301 (OR 4.2, 95% CI 1.0-17.3), DPB1*0201 (OR 4.0, 95% CI 1.0-15.7) and DQB1*0603 (OR 11.5, 95% CI 2.5-53.4).
|
7788177 |
1995 |