| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | disease | BEFREE | Foxp3 Molecular Dynamics in Treg in Juvenile Idiopathic Arthritis. | 30333832 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | In juvenile idiopathic arthritis (JIA) patients, we have previously reported that atypical CD25(+)FOXP3(-) Treg-like cells uniquely populate the inflamed site. | 26561546 | 2015 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | In this study, we report that, unlike in peripheral blood, CD4(+) T cell expression of CD25 and FOXP3 is frequently dissociated at the inflamed site in patients with juvenile idiopathic arthritis, which led us to question the stability of human Tregs in chronic inflammatory environments. | 25092890 | 2014 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Positive HLA-DR staining in the ileal mucosa was associated with the presence of high clinical disease activity of JIA and low mRNA expression of anti-inflammatory mediators, such as forkhead box protein P3 (FoxP3), glucocorticoid-induced tumour necrosis factor receptor-related protein (GITR) and transforming growth factor (TGF)-beta. | 23121667 | 2012 | ||||
|
0.070 | Biomarker | disease | BEFREE | Lastly, regulatory T cells (T(Reg)) of thymic origin (CD4(+)FOXP3(+)) were quantified in peripheral blood to assess the ability of the thymus in JIA to generate this T cell subset. | 18628282 | 2009 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | SNPs in the FOXP3 gene region show no association with Juvenile Idiopathic Arthritis in a UK Caucasian population. | 17526924 | 2007 | ||||
|
0.070 | Biomarker | disease | LHGDN | SNPs in the FOXP3 gene region show no association with Juvenile Idiopathic Arthritis in a UK Caucasian population. | 17526924 | 2007 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Our data show that patients with pers-OA JIA display a significantly higher frequency of CD4(+)CD25(bright) T cells with concomitant higher levels of mRNA FoxP3 in the peripheral blood than ext-OA JIA patients. | 15128835 | 2004 |