Peptides with disrupted helical structure [p5<sub>(coil)</sub> and p5<sub>(Pro3)</sub>], with an extended sheet conformation [p5<sub>(sheet)</sub>] or an all-D enantiomer [p5<sub>(D)</sub>], were chemically synthesized, radioiodinated, and their biodistribution studied in WT mice as well as transgenic animals with severe systemic AA amyloidosis.