| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | GeneticVariation | disease | BEFREE | The presence of a distinct CD38(+) population within the leukemic clone, rather than a numerical cutoff definition, correlates with IgV(H) gene mutational status and, irrespective of its size, identifies CLL patients who will have progressive disease. | 12406914 | 2003 | ||||
|
0.070 | Biomarker | disease | BEFREE | We undertook a longitudinal study close to diagnosis, pre-treatment and post relapse in 13 patients presenting with cMBL or Stage A disease and good-risk biomarkers (IGHV-M genes, no del(17p) or del(11q) and low CD38 expression) who nevertheless developed progressive disease, of whom 10 have required therapy. | 26847028 | 2016 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Cell-surface expression of CD38 in CLL has been recognised recently as a marker of progressive disease and poor outcome. | 16019444 | 2005 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | All expressed CD38 and had a progressive disease. | 15466924 | 2005 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | A high expression of CD49d (>30%) was found in 142/415 (34%) patients and was associated with progressive disease (advanced clinical stage, high serum lactate dehydrogenase or β2 -microglobulin levels; all p < 0·05) and aggressive disease biology (increased ZAP70 or CD38, unmutated IGHV, trisomy 12, mutations of NOTCH1 and SF3B1; all P < 0·05). | 26559905 | 2016 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | CD38 expression level and pattern of expression remains a reliable and robust marker of progressive disease in chronic lymphocytic leukemia. | 17107912 | 2006 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | In addition, mutated IgHV1-69 gene status was associated with lower cell surface CD38 expression and less progressive disease as monitored by Binet staging, lymphocyte doubling time and requirement of chemotherapeutic intervention. | 18398745 | 2008 |